播散性皮肤痛风:痛风的一种罕见表现

Yoon Jin Choi, J. Byun, You Won Choi, H. Choi
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摘要

一名 51 岁的男子在 3 周前出现双小腿多处炎症性皮损。他有 15 年痛风病史和 3 期慢性肾病。体格检查时发现,他的小腿、小腿、膝盖和脚踝处有多处淡黄色、坚实的丘疹,并有化脓的迹象(图 1)。皮肤活检显示,真皮深层有粉红色无定形物质的环状沉积,周围有组织细胞浸润和纤维反应。Von Kossa 染色未显示任何钙沉积(图 2)。该患者被诊断为播散性皮肤痛风,并使用局部类固醇和口服抗组胺药物对皮损进行对症治疗。痛风是一种以尿酸单钠(MSU)结晶沉积为特征的慢性疾病,当尿酸浓度升高时就会形成MSU结晶[1]。这些 MSU 晶体可积聚在关节、骨骼和各种身体组织中,包括皮肤和软组织。这种疾病可
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Disseminated cutaneous gout: a rare manifestation of gout
A 51-year-old man presented with multiple inflammatory skin lesions on both lower legs that had developed 3 weeks prior. He had a 15-year history of gout and stage 3 chronic kidney disease. Upon physical examination, multiple yellowish, firm papulonodules with evidence of suppuration were noted on his shins, calves, knees, and ankles (Fig. 1). A skin biopsy revealed well-circumscribed deposits of pinkish, amorphous material in the deep dermis, surrounded by histiocytic infiltration and a fibrous reaction. Von Kossa staining did not show any calcium deposition (Fig. 2). The patient was diagnosed with disseminated cutaneous gout, and the skin lesions were treated symptomatically with topical steroids and oral antihistamines. Gout is a chronic disease characterized by the deposition of monosodium urate (MSU) crystals, which form when urate concentrations are elevated [1]. These MSU crystals can accumulate in joints, bones, and various body tissues, including the skin and soft tissues. The disease can be
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