基于胶原蛋白的电纺纳米纤维用于增强护肤成分输送的临床研究

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cosmetics Pub Date : 2024-01-31 DOI:10.3390/cosmetics11010018
Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra
{"title":"基于胶原蛋白的电纺纳米纤维用于增强护肤成分输送的临床研究","authors":"Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra","doi":"10.3390/cosmetics11010018","DOIUrl":null,"url":null,"abstract":"Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients\",\"authors\":\"Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra\",\"doi\":\"10.3390/cosmetics11010018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.\",\"PeriodicalId\":10735,\"journal\":{\"name\":\"Cosmetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cosmetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/cosmetics11010018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cosmetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/cosmetics11010018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

纳米纤维材料因其独特的性能,在包括化妆品在内的多个应用领域引起了广泛关注。胶原蛋白是人体皮肤的主要结构蛋白,在保持皮肤健康、弹性和促进皮肤再生方面发挥着重要作用,因而备受关注。本研究报告了用于护肤应用的新型胶原蛋白纳米纤维平台 DermaLayr™ 的特性、安全性和功效评估。胶原蛋白纳米纤维采用声波电纺丝技术开发而成,扫描电子显微镜(SEM)分析表明,纳米纤维均匀一致,平均纤维直径在 250 到 300 nm 之间。对 EpiDerm™ 进行的皮肤渗透研究表明,与未经处理的样品相比,使用测试产品可使表皮层的胶原蛋白渗透率提高约 5-25%,真皮层的胶原蛋白渗透率提高约 16-20%。此外,还对所开发纳米纤维的安全性进行了体外和体内评估,这两项研究都表明纳米纤维具有无毒、无刺激的特性。此外,对人体进行的临床试验进一步证实了 DermaLayr™ 的临床疗效,表明它能显著改善皮肤的多项参数,如水合作用、弹性和整体皮肤健康。总之,本研究的结果强调了 DermaLayr™ 纳米纤维产品在化妆品和皮肤治疗中安全应用的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients
Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
期刊最新文献
Cosmetology in the Era of Artificial Intelligence Protective Effects of Recombined Mussel Adhesive Protein against AD Skin Inflammation in Mice Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation Design, Development, and In Vivo Testing of the Hydrating Effect and pH Maintenance a Cosmetic Formulation Incorporating Oils and an Extract from Peruvian Biodiversity Unwanted Skin Reactions to Acrylates: An Update
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1