聚乙二醇作为磁铁矿纳米粒子涂层二氧化硅的表面改性剂,有望成为一种热疗材料

H. Purwaningsih, Lehonnita Rotua Lectiodivirani Pakpahan, Vania Mitha Pratiwi, R. Fajarin, H. Nurdiansah, Diah Susanti
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引用次数: 0

摘要

局部热疗是癌症治疗方法之一,通过对癌细胞施加温度为 41-45°C 的热量来治疗癌症。这种方法被认为可以降低癌细胞周围正常细胞死亡的风险。热疗的形式本身是在铁流体中进行的。在其发展过程中,氧化铁超顺磁性纳米粒子因其良好的磁性和生物相容性吸引了各种研究。然而,由于颗粒间的相互作用较差,且容易聚集,因此有必要在超顺磁性上进行涂层处理。因此,在超顺磁性表面涂覆二氧化硅可降低聚集风险,提高材料的生物相容性。此外,还采用了聚乙二醇官能化技术,以提高材料的生物相容性,并作为铁流体的载体。试验采用磁铁矿共沉淀合成法和形成溶胶-凝胶二氧化硅涂层的方法进行。实验中应用的变化包括作为二氧化硅来源的 TEOS 浓度和颗粒与 PEG 的比例的影响。事实证明,添加二氧化硅可将磁矩值提高到 51.55 emu/g。在铁(III)纳米粒子中添加 TEOS 作为二氧化硅源可增加磁吸引力、降低表面张力值、减小粒径和降低 SAR 值。聚乙二醇的官能化具有降低磁矩、增加和降低疏水性、增加表面张力值和减小氧化铁(III)纳米粒子粒径的作用。这表明,事实证明,涂有聚乙二醇官能化二氧化硅的磁性纳米粒子在通交流电时会产生热量,其 SAR 值和最高温度是在温度为 32.2°C 和 SAR 值为 87.63 W/mg 的情况下,获得 3 毫升 PEG 比率为 2:5 的二氧化硅涂层的氧化铁(III)。
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Polyethylene Glycol as Surface Modification of Magnetite Nanoparticle Coated Silica a Potentially Hyperthermia Therapy Material
Local hyperthermia therapy is one of the cancer treatments by implementing heat from a temperature of 41-45°C on cancer cells. This method is believed to reduce the risk of normal cells around the cancer cells from dying. The form of hyperthermia therapy itself is in ferrofluid. During its development, superparamagnetic nanoparticles of iron oxide have attracted various studies because of their good magnetic properties and good biocompatibility. However, the poor particle interactions and their tendency to aggregation make coatings on superparamagnetic necessary. Therefore, silica coating on the superparamagnetic surface is carried out to reduce the risk of aggregation and increase the biocompatibility of the material. Polyethylene glycol functionalization was also applied to improve the biocompatibility of the material, as well as being a carrier for ferrofluid. The test was carried out using the magnetite co-precipitation synthesis method and the formation of a sol-gel silica coating. Variations applied in this experiment are the effects of TEOS concentration as a source of silica and the ratio of particles to PEG. The addition of silica was proven to increase the value of the magnetic moment to 51.55 emu/g. The addition of TEOS as a source of silica in iron (III) nanoparticles has an effect on increasing the magnetic attraction, decreasing the surface tension value, reducing particle size, and decreasing the SAR value. Functionalization of polyethylene glycol has the effect of reducing the magnetic moment, increasing and decreasing hydrophobicity, increasing the surface tension value, and reducing the particle size of iron (III) oxide nanoparticles. This shows that magnetic nanoparticles coated with silica with polyethylene glycol functionalization are proven to generate heat when given AC current with the SAR value and the highest temperature is found in iron (III) oxide which gets 3ml silica coating with a PEG ratio of 2:5 at a temperature of 32.2°C. and SAR value of 87.63 W/mg
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