Investigation of the Protective Effects of Capparis Spinosa Extract in Indomethacin Induced Ulcer Model in Rats

ABSTRACT Objective: Capparis spinosa is a genus of the Capparaceae family. In the literature, it has been found that the main components of Capparis buds, quercetin and kaempferol were found to be effective in many diseases. In this study, the protective effects of Capparis spinosa on damaged rat stomach tissue induced by indomethacin and some antioxidant parameters were investigated. Material and Methods: A total of 36 female Sprague Dawley rats weighing 200-220 grams were used in the study and six groups were formed. Groups were: healthy group; positive control group (famotidine 20 mg/kg + indomethacin 25 mg/kg); negative control group (distilled water + indomethacin); low-dose study group (125 mg/kg Capparis spinosa + indomethacin); medium dose group (250 mg/kg Capparis spinosa + indomethacin); and high dose group (500 mg/kg Capparis spinosa + indomethacin). Six hours after indomethacin was given to the groups by gastric lavage, all rats were killed under general anesthesia. The stomachs of all rats were removed, the ulcerated areas on the stomach surface were evaluated macroscopically, and the ulcer areas were measured on mm2 paper. In addition, blood and stomach tissues of all rats were biochemically examined, and malondialdehyde, superoxide dismutase and glutathione parameters were measured. The antiulcer activity of CS was compared with all groups. Results: When the ulcer area and histopathological evaluation were examined, it was determined that the group applied 250 mg/kg Capparis spinosa had an appearance close to the healthy group. It was also found that plant extracts at all concentrations decreased the level of MDA in rat gastric tissue and increased SOD activity and GSH levels statistically. Conclusion: It was obtained that Capparis spinosa has antiulcer activity.