Objective: Atherosclerosis and cancer are chronic diseases that are considered to be two of the most common causes of death. Given that both diseases are chronic multifactorial, they may also share many etiological and mechanistic processes. Inflammatory processes and oxidative stress are also important factors in the development of both atherosclerosis and cancer. The aim of this study is to provide new evidence, not included in the literature, between calculable atherogenicity risk indices and basal cell carcinoma (BCC) formation, and to encourage the identification of closer molecular links between these two pathologies. Materials and Methods: Atherogenic plasma index (AIP), atherogenic index (AI) and Lipoprotein combined index (LCI) were calculated using mathematical formulas and routine lipid values. The routine lipid parametres and atherogenic index values of the BCC patients (n: 39) were compared with the controls (n: 44). Unpaired t-test were used for parameters with normal distribution and Mann-Whitney test were used for non-normally distributed parameters. Results: Among the serum lipid parameters, only low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) were significantly increased in the patient group. However, all atherogenic indices (AIP, AI and LCI) were found to be statistically significantly higher in the patient group (p
{"title":"Increased Atherogenic Indices and Basal Cell Carcinoma","authors":"Cemile ÖZ KAYMAZ, N. Yılmaz, E. Eren","doi":"10.56766/ntms.1297303","DOIUrl":"https://doi.org/10.56766/ntms.1297303","url":null,"abstract":"Objective: Atherosclerosis and cancer are chronic diseases that are considered to be two of the most common causes of death. Given that both diseases are chronic multifactorial, they may also share many etiological and mechanistic processes. Inflammatory processes and oxidative stress are also important factors in the development of both atherosclerosis and cancer. The aim of this study is to provide new evidence, not included in the literature, between calculable atherogenicity risk indices and basal cell carcinoma (BCC) formation, and to encourage the identification of closer molecular links between these two pathologies. \u0000Materials and Methods: Atherogenic plasma index (AIP), atherogenic index (AI) and Lipoprotein combined index (LCI) were calculated using mathematical formulas and routine lipid values. The routine lipid parametres and atherogenic index values of the BCC patients (n: 39) were compared with the controls (n: 44). Unpaired t-test were used for parameters with normal distribution and Mann-Whitney test were used for non-normally distributed parameters. \u0000Results: Among the serum lipid parameters, only low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) were significantly increased in the patient group. However, all atherogenic indices (AIP, AI and LCI) were found to be statistically significantly higher in the patient group (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"277 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayse Sena Donmez Donmez, K. Tekgündüz, Mustafa Kara
Objective: Late preterm newborns are defined as infants born at 34-36 weeks of gestation, while early term newborns are those born at 37-38 weeks. Late preterm and early term newborns have higher risks of morbidity and mortality compared to term infants. The aim of this study was to investigate the causes of neonatal morbidity and mortality in late preterm and early term newborns with reference to term newborns. Materials and Methods: A total of 1000 newborns born between 34 and 42 weeks of gestation in our hospital were included in this study. These cases were evaluated according to maternal age, birth weight, APGAR score, mode of delivery, need for postnatal resuscitation, family income, hospitalization rate, and need for mechanical ventilation. Results: Among the 1000 newborns included in the study, respiratory problems were more common in male newborns. As income levels increased, the rate of births closer to term increased. The hospitalization rate of late preterm newborns was higher compared to early term and term newborns while APGAR scores were lower. Finally, the need for mechanical ventilation was higher among late preterm newborns. Conclusion: In evaluations of late preterm and early term newborns, their physiological immaturity should be considered and it should not be forgotten that they have higher risks in terms of morbidity and mortality. Delivery should not be planned before the 39th week of gestation unless there is a medical indication.
{"title":"Postnatal Hospitalization Rates and Short-Term Follow-up Results of Late Preterm, Early Term, and Term Newborns","authors":"Ayse Sena Donmez Donmez, K. Tekgündüz, Mustafa Kara","doi":"10.56766/ntms.1407161","DOIUrl":"https://doi.org/10.56766/ntms.1407161","url":null,"abstract":"Objective: Late preterm newborns are defined as infants born at 34-36 weeks of gestation, while early term newborns are those born at 37-38 weeks. Late preterm and early term newborns have higher risks of morbidity and mortality compared to term infants. The aim of this study was to investigate the causes of neonatal morbidity and mortality in late preterm and early term newborns with reference to term newborns. \u0000Materials and Methods: A total of 1000 newborns born between 34 and 42 weeks of gestation in our hospital were included in this study. These cases were evaluated according to maternal age, birth weight, APGAR score, mode of delivery, need for postnatal resuscitation, family income, hospitalization rate, and need for mechanical ventilation. \u0000Results: Among the 1000 newborns included in the study, respiratory problems were more common in male newborns. As income levels increased, the rate of births closer to term increased. The hospitalization rate of late preterm newborns was higher compared to early term and term newborns while APGAR scores were lower. Finally, the need for mechanical ventilation was higher among late preterm newborns. \u0000Conclusion: In evaluations of late preterm and early term newborns, their physiological immaturity should be considered and it should not be forgotten that they have higher risks in terms of morbidity and mortality. Delivery should not be planned before the 39th week of gestation unless there is a medical indication.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"134 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Aydin, Mustafa Can Güler, Mehmet Hakan Şahi̇n, Erkan Cem Celik, O. N. Keleş
Background: Electric and magnetic field-generating systems must be insulated in order to maintain their balance. It is certain that the brain, which has a very intense electric and magnetic field, is insulated by the dura mater and cerebrospinal fluid (CSF) that surround it. In this article, the electrophysical properties of these structures will be postulated in accordance with the laws of mathematics and physics. Material and Methods: In human samples, on the other hand, the morphological features of EEG waves were examined with parameters such as the number of scalp hairs and scalp thickness, conductivity, skull thickness, ratios between cranial and brain volumes, and the thickness of the subarachnoid space where CSF circulates, and ventricular volumes. Since this study is postulative, the data were not detailed by statistical evaluation. Results: With the geometric shapes of EEG waves; scalp thickness and number of hairs, skull thickness, depth of subarachnoid space, ventricular volumes, thickness of dura mater. EEG artifacts were excessive in pediatric cases with closed fontanelles or in adults with bone defects. There were statistically varying safety limits between 0.05
{"title":"A Newly Defined Electromagnetic Dural Armor Functioned as a Brain Protecting Cerebrosphere: A Preliminary Theoretical Analysis","authors":"M. Aydin, Mustafa Can Güler, Mehmet Hakan Şahi̇n, Erkan Cem Celik, O. N. Keleş","doi":"10.56766/ntms.1419119","DOIUrl":"https://doi.org/10.56766/ntms.1419119","url":null,"abstract":"Background: Electric and magnetic field-generating systems must be insulated in order to maintain their balance. It is certain that the brain, which has a very intense electric and magnetic field, is insulated by the dura mater and cerebrospinal fluid (CSF) that surround it. In this article, the electrophysical properties of these structures will be postulated in accordance with the laws of mathematics and physics. \u0000Material and Methods: In human samples, on the other hand, the morphological features of EEG waves were examined with parameters such as the number of scalp hairs and scalp thickness, conductivity, skull thickness, ratios between cranial and brain volumes, and the thickness of the subarachnoid space where CSF circulates, and ventricular volumes. Since this study is postulative, the data were not detailed by statistical evaluation. \u0000Results: With the geometric shapes of EEG waves; scalp thickness and number of hairs, skull thickness, depth of subarachnoid space, ventricular volumes, thickness of dura mater. EEG artifacts were excessive in pediatric cases with closed fontanelles or in adults with bone defects. There were statistically varying safety limits between 0.05","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Albayrak, Akif Ali̇yev, Mirza Ali̇yev, Y. Bayir, Erdem Toktay, Z. Halıcı
ABSTRACT Objective: Capparis spinosa is a genus of the Capparaceae family. In the literature, it has been found that the main components of Capparis buds, quercetin and kaempferol were found to be effective in many diseases. In this study, the protective effects of Capparis spinosa on damaged rat stomach tissue induced by indomethacin and some antioxidant parameters were investigated. Material and Methods: A total of 36 female Sprague Dawley rats weighing 200-220 grams were used in the study and six groups were formed. Groups were: healthy group; positive control group (famotidine 20 mg/kg + indomethacin 25 mg/kg); negative control group (distilled water + indomethacin); low-dose study group (125 mg/kg Capparis spinosa + indomethacin); medium dose group (250 mg/kg Capparis spinosa + indomethacin); and high dose group (500 mg/kg Capparis spinosa + indomethacin). Six hours after indomethacin was given to the groups by gastric lavage, all rats were killed under general anesthesia. The stomachs of all rats were removed, the ulcerated areas on the stomach surface were evaluated macroscopically, and the ulcer areas were measured on mm2 paper. In addition, blood and stomach tissues of all rats were biochemically examined, and malondialdehyde, superoxide dismutase and glutathione parameters were measured. The antiulcer activity of CS was compared with all groups. Results: When the ulcer area and histopathological evaluation were examined, it was determined that the group applied 250 mg/kg Capparis spinosa had an appearance close to the healthy group. It was also found that plant extracts at all concentrations decreased the level of MDA in rat gastric tissue and increased SOD activity and GSH levels statistically. Conclusion: It was obtained that Capparis spinosa has antiulcer activity.
{"title":"Investigation of the Protective Effects of Capparis Spinosa Extract in Indomethacin Induced Ulcer Model in Rats","authors":"A. Albayrak, Akif Ali̇yev, Mirza Ali̇yev, Y. Bayir, Erdem Toktay, Z. Halıcı","doi":"10.56766/ntms.1171430","DOIUrl":"https://doi.org/10.56766/ntms.1171430","url":null,"abstract":"ABSTRACT \u0000Objective: Capparis spinosa is a genus of the Capparaceae family. In the literature, it has been found that the main components of Capparis buds, quercetin and kaempferol were found to be effective in many diseases. In this study, the protective effects of Capparis spinosa on damaged rat stomach tissue induced by indomethacin and some antioxidant parameters were investigated. \u0000Material and Methods: A total of 36 female Sprague Dawley rats weighing 200-220 grams were used in the study and six groups were formed. Groups were: healthy group; positive control group (famotidine 20 mg/kg + indomethacin 25 mg/kg); negative control group (distilled water + indomethacin); low-dose study group (125 mg/kg Capparis spinosa + indomethacin); medium dose group (250 mg/kg Capparis spinosa + indomethacin); and high dose group (500 mg/kg Capparis spinosa + indomethacin). Six hours after indomethacin was given to the groups by gastric lavage, all rats were killed under general anesthesia. The stomachs of all rats were removed, the ulcerated areas on the stomach surface were evaluated macroscopically, and the ulcer areas were measured on mm2 paper. In addition, blood and stomach tissues of all rats were biochemically examined, and malondialdehyde, superoxide dismutase and glutathione parameters were measured. The antiulcer activity of CS was compared with all groups. \u0000Results: When the ulcer area and histopathological evaluation were examined, it was determined that the group applied 250 mg/kg Capparis spinosa had an appearance close to the healthy group. It was also found that plant extracts at all concentrations decreased the level of MDA in rat gastric tissue and increased SOD activity and GSH levels statistically. \u0000Conclusion: It was obtained that Capparis spinosa has antiulcer activity.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140481414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIM: Folic acid decreases physiologically during pregnancy and this situation predisposes to congenital anomalies such as neural tube defects and spina bifida. The aim of our study was to measure the level of knowledge of women about the use of folic acid in the preconceptional period. METHODS: In this study, we conducted a questionnaire study questioning the level of knowledge about folic acid among women aged 18-49 years and female health care workers who applied to Van YYÜ Dursun Odabaş Medical Center Family Medicine outpatient clinics and statistical analyses were evaluated in SPSS (ver. 20) program. RESULTS: Of the 400 women who participated in our study, 47% were healthcare workers and 53% were patients. To the question "Have you heard of folic acid before?" 78.3% of the participants answered "Yes" and 21.9% answered "No". "Among 206 individuals with a history of previous pregnancy, 51.9% answered "Yes" and 48.1% answered "No" to the question. In the study, it was observed that the level of knowledge about folic acid and folic acid use was higher in younger age groups, health workers, single women, university graduates, those with higher income levels and those with fewer parities. CONCLUSION: It was concluded that the level of knowledge and awareness of folic acid is not at an adequate level and folic acid awareness of women of reproductive age should be increased. In order to increase this awareness at the social level, family physicians, midwives or nurses, whom the public will reach in the first place, should inform the patients.
{"title":"Evaluation of Women's Knowledge Levels About Folic Acid; An Example of a University Hospital","authors":"Hülya Altindağ, Mehmet Emin Layik","doi":"10.56766/ntms.1388150","DOIUrl":"https://doi.org/10.56766/ntms.1388150","url":null,"abstract":"AIM: Folic acid decreases physiologically during pregnancy and this situation predisposes to congenital anomalies such as neural tube defects and spina bifida. The aim of our study was to measure the level of knowledge of women about the use of folic acid in the preconceptional period. \u0000METHODS: In this study, we conducted a questionnaire study questioning the level of knowledge about folic acid among women aged 18-49 years and female health care workers who applied to Van YYÜ Dursun Odabaş Medical Center Family Medicine outpatient clinics and statistical analyses were evaluated in SPSS (ver. 20) program. \u0000RESULTS: Of the 400 women who participated in our study, 47% were healthcare workers and 53% were patients. To the question \"Have you heard of folic acid before?\" 78.3% of the participants answered \"Yes\" and 21.9% answered \"No\". \"Among 206 individuals with a history of previous pregnancy, 51.9% answered \"Yes\" and 48.1% answered \"No\" to the question. In the study, it was observed that the level of knowledge about folic acid and folic acid use was higher in younger age groups, health workers, single women, university graduates, those with higher income levels and those with fewer parities. \u0000CONCLUSION: It was concluded that the level of knowledge and awareness of folic acid is not at an adequate level and folic acid awareness of women of reproductive age should be increased. In order to increase this awareness at the social level, family physicians, midwives or nurses, whom the public will reach in the first place, should inform the patients.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140495350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scientific research on medicinal plants is increasing day by day. Hippophae rhamnoides L. is a medicinal plant, which belongs to the family of L. Elaeagnaceae, and is consumed as a medicinal and food at the same time. It is a type of plant in the form of a bush with thorny, nitrogen-fixing roots and fruit that grows in cold and arid regions. It is native to and widely found in cold temperate regions of Europe and Asia. The species differ in their phytochemical compositions, depending on the climate and the soil they grow in. Due to its rich chemical composition, it has been used in traditional medicine for centuries as herbal medicine, health promoter, and food additive. Hippophae rhamnoides L. plant; It has attracted worldwide attention due to the presence of different types of nutrients and bioactive compounds such as vitamins, amino acids, fatty acids, carotenoids, phenolic compounds, and micro and macro elements, including its leaves, fruits, and seeds. Hippophae rhamnoides L. contains phytochemicals besides reducing platelet aggregation, blood pressure, and blood sugar; It has been reported to have a wide range of activities ranging from anticarcinogen, antifungal, antibacterial, antioxidant, antihistaminic, antiviral, anti-inflammatory, spasmolytic, gastroprotective, cardioprotective and radioprotective potential. In addition, it is promising to be used as an alternative support for the treatment of diseases such as skin burns and atopic dermatitis, since it protects and regulates cell metabolism and has a protective effect on skin cells. Hippophae rhamnoides L., which has economic value with the rich components it contains, is used in the medical, food, and cosmetic industries, while at the same time, it is used as a feed additive for animals and to prevent the destruction of the field by flood waters for ecological purposes. Studies on the plant Hippophae rhamnoides L. are important due to the use of a wide spectrum. The aim of this review is to give information about the botanical, medicinal, traditional and current uses of the fruit and plant of Hippophae rhamnoides L.
{"title":"Hippophae Rhamnoides L. Botanical, Medicinal, Traditional, and Current Use of Plant and Fruits: A Review","authors":"Hilal Bayir, Büşra İrem Şi̇mşek, Y. Bayir","doi":"10.56766/ntms.1324265","DOIUrl":"https://doi.org/10.56766/ntms.1324265","url":null,"abstract":"Scientific research on medicinal plants is increasing day by day. Hippophae rhamnoides L. is a medicinal plant, which belongs to the family of L. Elaeagnaceae, and is consumed as a medicinal and food at the same time. It is a type of plant in the form of a bush with thorny, nitrogen-fixing roots and fruit that grows in cold and arid regions. It is native to and widely found in cold temperate regions of Europe and Asia. The species differ in their phytochemical compositions, depending on the climate and the soil they grow in. Due to its rich chemical composition, it has been used in traditional medicine for centuries as herbal medicine, health promoter, and food additive. Hippophae rhamnoides L. plant; It has attracted worldwide attention due to the presence of different types of nutrients and bioactive compounds such as vitamins, amino acids, fatty acids, carotenoids, phenolic compounds, and micro and macro elements, including its leaves, fruits, and seeds. Hippophae rhamnoides L. contains phytochemicals besides reducing platelet aggregation, blood pressure, and blood sugar; It has been reported to have a wide range of activities ranging from anticarcinogen, antifungal, antibacterial, antioxidant, antihistaminic, antiviral, anti-inflammatory, spasmolytic, gastroprotective, cardioprotective and radioprotective potential. In addition, it is promising to be used as an alternative support for the treatment of diseases such as skin burns and atopic dermatitis, since it protects and regulates cell metabolism and has a protective effect on skin cells. Hippophae rhamnoides L., which has economic value with the rich components it contains, is used in the medical, food, and cosmetic industries, while at the same time, it is used as a feed additive for animals and to prevent the destruction of the field by flood waters for ecological purposes. Studies on the plant Hippophae rhamnoides L. are important due to the use of a wide spectrum. The aim of this review is to give information about the botanical, medicinal, traditional and current uses of the fruit and plant of Hippophae rhamnoides L.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"69 9-10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allergic diseases are very common in children. The aim of this study is to obtain information about the frequency and risk factors of allergic diseases in kindergarten children aged 3-6 years. This study was carried out between 13.02.2018 and 30.12.2018 in kindergartens, in accordance with the ISAAC Phase I protocol for children aged 3-6 years. The study was carried out by distributing 3000 questionnaires in 20 kindergartens. 2001 out of 2040 collected questionnaires were included in the study. Of the participants, 986 (49.3%) were female and 1015 (50.7%) were male. The frequency of asthma symptoms was 30.4% (n=608). The frequency of allergic rhinitis symptoms was found to be 37.1% (743 people). The risk of asthma symptoms was significantly higher in males, those whose mothers smoked during pregnancy, those born preterm, those with a smoker at home and those with mold in the home (p
{"title":"Prevalence of Allergic Diseases and Risk Factors in Preschool Children","authors":"Nafiz SARIŞIK, Ugur ALTAS, Mehmet Yaşar ÖZKARS","doi":"10.56766/ntms.1345987","DOIUrl":"https://doi.org/10.56766/ntms.1345987","url":null,"abstract":"Allergic diseases are very common in children. The aim of this study is to obtain information about the frequency and risk factors of allergic diseases in kindergarten children aged 3-6 years. This study was carried out between 13.02.2018 and 30.12.2018 in kindergartens, in accordance with the ISAAC Phase I protocol for children aged 3-6 years. The study was carried out by distributing 3000 questionnaires in 20 kindergartens. 2001 out of 2040 collected questionnaires were included in the study. Of the participants, 986 (49.3%) were female and 1015 (50.7%) were male. The frequency of asthma symptoms was 30.4% (n=608). The frequency of allergic rhinitis symptoms was found to be 37.1% (743 people). The risk of asthma symptoms was significantly higher in males, those whose mothers smoked during pregnancy, those born preterm, those with a smoker at home and those with mold in the home (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To prospectively assess the effects of intravenous patient-controlled analgesia (IV PCA) and epidural patient-controlled analgesia (epidural PCA) on postoperative pain management following posterior instrumentation surgery.
Materials and Methods: The study involved the ASA 1-2 group, 60 patients who underwent elective thoracic or lumbar posterior instrumentation surgery at our tertiary centre for spinal stenosis. Two groups of patients were created: Group 1 (n = 30), IV PCA group, and Group 2 (n=30), epidural PCA group. IV PCA was applied by fentanyl. Epidural PCA was maintained by lading to epidural space by the neurosurgeon. Bupivacaine was administered to Group 2 patients in the recovery room. Following surgery, patients in both groups were assessed for pain using the visual analogue scale (VAS) and for motor block using the Bromage scale. Additionally, hemodynamic parameters, side effects, and patient satisfaction were noted. Following 48 hours, patients' overall rescue analgesia, opioid, and local anaesthetic requirements were recorded.
Results: Postoperative VAS scores of Group 2 at the 1st, 2nd, 4th, 8th and 16th hours were lower than Group 1 and these differences was statistically significant. Postoperative patient satisfaction scores at 1st, 2nd, 4th, 8th, 12th, 16th, 20th, 24th, 30th, 36th, 42nd and 48th hours were significantly different between the groups and the patient satisfaction scores of Group 2 were higher than the Group 1. Side effects were similar in both groups. Group 1 required statistically significantly higher number of rescue analgesia.
Conclusion: This study shows that epidural PCA is more comfortable than IV PCA with low VAS and high patient satisfaction scores. As a conclusion, epidural PCA is a safe, highly efficient method for patients with posterior instrumentation surgery.
{"title":"Comparison of the postoperative analgesia effects of patient-controlled analgesia (PCA) and epidural catheter after posterior instrumentation surgery","authors":"Muhammet Ahmet KARAKAYA, Hacı Ahmet ALICI","doi":"10.56766/ntms.1357854","DOIUrl":"https://doi.org/10.56766/ntms.1357854","url":null,"abstract":"Objective: To prospectively assess the effects of intravenous patient-controlled analgesia (IV PCA) and epidural patient-controlled analgesia (epidural PCA) on postoperative pain management following posterior instrumentation surgery.
 Materials and Methods: The study involved the ASA 1-2 group, 60 patients who underwent elective thoracic or lumbar posterior instrumentation surgery at our tertiary centre for spinal stenosis. Two groups of patients were created: Group 1 (n = 30), IV PCA group, and Group 2 (n=30), epidural PCA group. IV PCA was applied by fentanyl. Epidural PCA was maintained by lading to epidural space by the neurosurgeon. Bupivacaine was administered to Group 2 patients in the recovery room. Following surgery, patients in both groups were assessed for pain using the visual analogue scale (VAS) and for motor block using the Bromage scale. Additionally, hemodynamic parameters, side effects, and patient satisfaction were noted. Following 48 hours, patients' overall rescue analgesia, opioid, and local anaesthetic requirements were recorded. 
 Results: Postoperative VAS scores of Group 2 at the 1st, 2nd, 4th, 8th and 16th hours were lower than Group 1 and these differences was statistically significant. Postoperative patient satisfaction scores at 1st, 2nd, 4th, 8th, 12th, 16th, 20th, 24th, 30th, 36th, 42nd and 48th hours were significantly different between the groups and the patient satisfaction scores of Group 2 were higher than the Group 1. Side effects were similar in both groups. Group 1 required statistically significantly higher number of rescue analgesia. 
 Conclusion: This study shows that epidural PCA is more comfortable than IV PCA with low VAS and high patient satisfaction scores. As a conclusion, epidural PCA is a safe, highly efficient method for patients with posterior instrumentation surgery.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135919882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective:
The aim of this study is to conduct a detailed examination of cases of "Early Recurrence" encountered following lumbar disc herniation, and to compare the data obtained with findings in the existing literature.
Materials and Methods:
This retrospective study was conducted by analyzing the data of 856 patients who were operated for recurrent lumbar hernia in our hospital between 2012 and 2022. By expanding the definition of "early relapse" in the literature, inclusion and exclusion criteria were determined, and as a result, 43 patients who met the criteria were included in the study
Results:
The severity of symptoms was assessed based on patients' Visual Analog Scale (VAS) scores at baseline and during subsequent periods. Patients requiring reoperation within the first 12 months were divided into two main groups: those undergoing reoperation within the first 6 months and those undergoing reoperation between 6-12 months. However, no statistically significant difference was found between the two groups in terms of age, gender, comorbidities, and other determinants. Notably, patients undergoing surgery within the first 3 months were observed to be of advanced age.
Conclusion:
When comparing the data obtained from analyzing patients with "early recurrent lumbar disc herniation" with findings shared in the literature, we found that similar variables were not significant in our series. An interesting observation is that both full endoscopic and microscopic methods have similar early recurrence rates. This is particularly noteworthy because full endoscopic discectomy usually involves sequestrectomy, and the volume of the disk removed is typically minimal. Hence, our study suggests that the volume of the disk removed during surgery may not be as influential in the development of early recurrence as previously thought. These findings provide an important foundation for future research.
{"title":"EARLY RECURRENCE OF LUMBAR DİSC HERNİATİON: A RETROSPECTİVE ANALYSİS OF THE ROLE OF DİSCECTOMY VOLUME AND OTHER INFLUENCİNG FACTORS","authors":"Derya KARAOĞLU GÜNDOĞDU, Burak GEZER, Ender KÖKTEKİR, Hakan KARABAĞLI","doi":"10.56766/ntms.1356688","DOIUrl":"https://doi.org/10.56766/ntms.1356688","url":null,"abstract":"Objective:
 The aim of this study is to conduct a detailed examination of cases of \"Early Recurrence\" encountered following lumbar disc herniation, and to compare the data obtained with findings in the existing literature.
 Materials and Methods:
 This retrospective study was conducted by analyzing the data of 856 patients who were operated for recurrent lumbar hernia in our hospital between 2012 and 2022. By expanding the definition of \"early relapse\" in the literature, inclusion and exclusion criteria were determined, and as a result, 43 patients who met the criteria were included in the study
 Results:
 The severity of symptoms was assessed based on patients' Visual Analog Scale (VAS) scores at baseline and during subsequent periods. Patients requiring reoperation within the first 12 months were divided into two main groups: those undergoing reoperation within the first 6 months and those undergoing reoperation between 6-12 months. However, no statistically significant difference was found between the two groups in terms of age, gender, comorbidities, and other determinants. Notably, patients undergoing surgery within the first 3 months were observed to be of advanced age.
 Conclusion:
 When comparing the data obtained from analyzing patients with \"early recurrent lumbar disc herniation\" with findings shared in the literature, we found that similar variables were not significant in our series. An interesting observation is that both full endoscopic and microscopic methods have similar early recurrence rates. This is particularly noteworthy because full endoscopic discectomy usually involves sequestrectomy, and the volume of the disk removed is typically minimal. Hence, our study suggests that the volume of the disk removed during surgery may not be as influential in the development of early recurrence as previously thought. These findings provide an important foundation for future research.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135919502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma ÖZCAN SIKI, Mehmet SARIKAYA, Metin GÜNDÜZ, Tamer SEKMENLİ, İlhan ÇİFTCİ, İsa YILMAZ, Harun PERU
BACKGROUND: Primary megaureter (PM) is a common congenital uropathy. In this study, we compared the results of treatment options for primary megaureter with obstruction in UVJ.
METHODS: The files of all patients who underwent open surgery and had a double J (JJ) ureteral stent for treating primary obstructive megaureter in our institution between 2010 and 2023 were evaluated retrospectively. The demographic information of the patients, the results of imaging tests before and after the surgery, early and late complications after the treatment, and the length of stay in the hospital were recorded. The results of both treatment methods were compared statistically.
RESULTS: A total of 23 patients and 26 kidney units over 13 years were retrospectively analyzed. Eighteen patients were male (78%); 5 were girls (22%). Ureteral tapering and ureteroneocystostomy (UNC) were performed with open surgery in 8 patients, while JJ stent was placed in 12 patients primarily by cystoscopy. In the urinary system ultrasonography (USS) performed at an average of 3 months after the treatment, hydronephrosis grades were observed to regress in 25 units. All patients recovered after surgery and there was no significant difference between the two treatment methods (p> 0.05).
CONCLUSION: In the treatment of primary obstructive megaureter (POM), endoscopic JJ stenting is as effective as ureteral reimplantation with open surgery. It may be considered more valuable due to the shorter hospital stay
{"title":"COMPARISON OF TREATMENT METHODS OF PRIMARY OBSTRUCTIVE MEGAURETER","authors":"Fatma ÖZCAN SIKI, Mehmet SARIKAYA, Metin GÜNDÜZ, Tamer SEKMENLİ, İlhan ÇİFTCİ, İsa YILMAZ, Harun PERU","doi":"10.56766/ntms.1358523","DOIUrl":"https://doi.org/10.56766/ntms.1358523","url":null,"abstract":"BACKGROUND: Primary megaureter (PM) is a common congenital uropathy. In this study, we compared the results of treatment options for primary megaureter with obstruction in UVJ.
 METHODS: The files of all patients who underwent open surgery and had a double J (JJ) ureteral stent for treating primary obstructive megaureter in our institution between 2010 and 2023 were evaluated retrospectively. The demographic information of the patients, the results of imaging tests before and after the surgery, early and late complications after the treatment, and the length of stay in the hospital were recorded. The results of both treatment methods were compared statistically.
 RESULTS: A total of 23 patients and 26 kidney units over 13 years were retrospectively analyzed. Eighteen patients were male (78%); 5 were girls (22%). Ureteral tapering and ureteroneocystostomy (UNC) were performed with open surgery in 8 patients, while JJ stent was placed in 12 patients primarily by cystoscopy. In the urinary system ultrasonography (USS) performed at an average of 3 months after the treatment, hydronephrosis grades were observed to regress in 25 units. All patients recovered after surgery and there was no significant difference between the two treatment methods (p> 0.05).
 CONCLUSION: In the treatment of primary obstructive megaureter (POM), endoscopic JJ stenting is as effective as ureteral reimplantation with open surgery. It may be considered more valuable due to the shorter hospital stay","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135919881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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