恢复行动能力:同时锻炼对 T2DM 相关性 PAD 患者功能性跛行距离和血管健康的影响

Uroosa Amin, Q. Adnan, Dr. Tauseef Ahmad
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摘要

背景:在全球范围内,过去几十年来,糖尿病在普通人群中的流行率不断上升。尽管二型糖尿病的发病率较高,但有关糖尿病相关血管并发症的证据却很少。因此,本研究旨在确定在临床环境中有效进行适当的运动训练,减少 T2DM 相关 PAD 患者的风险因素:方法:2023 年 7 月至 9 月,卡拉奇齐亚乌丁医生医院康复科学部进行了一项随机、单盲、双臂试验。招募了 80 名 T2DM 相关 PAD 患者,并采用密封信封法将其随机分配到两组:A组(40人)和B组(40人)。在为期 12 周的时间里,B 组参与者进行有氧训练 (AT),而 A 组参与者每周进行 3 次同步训练 (CT)。在干预前和干预后测量功能性跛行距离(FCD)和VascuQol-6,以衡量功能能力和血管健康状况。结果:结果显示,12周后,CT训练组的FCD和VascuQol-6均有明显改善(P<0.000)。随后的研究结果显示,CT 组在改善 FCD 方面比 AT 组有更明显的改善(P=0.013,CT:前:203.33±1.78,后:230.65±7.72,P=0.013):230.65±7.72,AT:前:203.08±2.2,后:214.13±5.1:214.13±5.1)和 VascuQol-6(P=0.0001,CT:前:10.60±2.11,后:19.88±1.2419.88±1.24,AT:前:9.53±2,后:14.33±1.97):14.33±1.97).Conclusion:结论:与 AT 组相比,CT 组患者的血管健康和 FCD 有明显改善。因此,CT 似乎是治疗方丹 II 期(一种与 T2DM 相关的 PAD)的一种非常有益的治疗策略:跛行距离 糖尿病血管并发症 周围动脉疾病 2型糖尿病 血管生活质量
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Rejuvenating Mobility: Impact of Concurrent Exercise on Functional Claudication Distance and Vascular Health among Patients with T2DM-Associated PAD
Background: Globally, the diabetes epidemic has increased in the general population over the last few decades. Despite the higher prevalence of Type-II DM, evidence about Diabetes-related vascular complications is scarce. Therefore, this study aims to determine appropriate exercise training in clinical settings effectively, reducing risk factors for T2DM-associated PAD patients. Methods: At the Department of Rehabilitation Sciences of Dr. Ziauddin Hospital Karachi, a randomized, single-blinded, two-arm trial was conducted from July to September 2023. Eighty patients with T2DM-associated PAD were recruited and randomly assigned into two groups Using the sealed envelope approach: Group A (n=40) and Group B (n=40). For 12 weeks, participants in Group B performed Aerobic Training (AT), while Group A participated in Concurrent Training (CT) 3 times a week. Functional Claudication Distance (FCD) and VascuQol-6 were measured pre and post-12-week intervention for measuring functional capacity and vascular health. Results:Findings revealed that CT training groups significantly improved FCD and VascuQol-6 after 12 weeks (p<0.000). Subsequently, findings showed that the CT group showed more significant improvement than AT in improving FCD (p=0.013, CT: pre: 203.33±1.78, post: 230.65±7.72, AT: pre: 203.08±2.2, post: 214.13±5.1) and VascuQol-6 (p=0.0001, CT: pre: 10.60±2.11, post: 19.88±1.24, AT: pre: 9.53±2, post: 14.33±1.97). Conclusion: Patients’ reported vascular health and FCD significantly improved by the CT than the AT group. Therefore, CT appears to be an exceptionally beneficial therapeutic strategy for the management of Fontaine’s stage II, a PADassociated with T2DM. Keywords: Claudication Distance, Diabetic Vascular Complication, Peripheral Artery Disease, Type-2 Diabetes Mellitus, Vascular Quality of Life.
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