雷米芬太尼与芬太尼静脉注射治疗心脏手术后患者血糖升高的比较

Irvan 1a, Doddy Tavianto, R. W. Sudjud
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引用次数: 0

摘要

导言:在没有糖尿病史的心脏病患者中,接受心脏手术的高血糖发生率高达 50%。高血糖会增加发病率和死亡率。研究目的本研究旨在评估使用瑞芬太尼(remifentanil)静脉注射 0.5-1 µg/kgBW 螺栓,然后以 0.05-0.1 µg/kgBW/min 的剂量静脉注射维持,与使用芬太尼(fentanyl)3-10 µg/kgBW,然后以 0.03-0.1 µg/kgBW/min 的剂量静脉注射维持相比,对接受心肺旁路(CPB)手术的心脏手术患者血糖水平升高的影响。材料和方法:本研究是一项采用单盲随机对照设计的实验研究。患者将被分为两组,每组 12 人,即 R 组(瑞芬太尼)接受瑞芬太尼,F 组(芬太尼)接受芬太尼。手术前后将检查血糖水平。研究结果研究于 2023 年 2 月至 2023 年 5 月在万隆哈桑-萨迪金博士医院进行。瑞芬太尼组的血糖水平平均上升了 74 毫克/分升,而芬太尼组则上升了 90 毫克/分升。给出的 p 值为 0.214。统计检验结果显示,P 值大于 0.05。结论本研究得出结论,两组(瑞芬太尼组和芬太尼组)之间的血糖水平升高没有明显差异。这可能是由于我们的研究中使用的阿片类药物剂量范围较小,且手术过程较为复杂。
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Comparison of Intravenous Administration of Remifentanil with Fentanyl for Increased Blood Sugar Levels in Post Cardiac Surgery Patients
Introduction: The incidence of hyperglycemia in patients with heart disease undergoing cardiac surgery reaches 50% in patients without a history of Diabetes Mellitus. This condition of hyperglycemia can increase morbidity and mortality. Objective: This study aims to assess the effect of using the agent remifentanil intravenously 0.5-1 µg/kgBW bolus followed by maintenance at a dose of 0.05-0.1 µg/kgBW/minute intravenously compared to the use of fentanyl 3-10 µg/kgBW followed by a maintenance dose of 0.03-0.1 µg/kgBW/minute for increased blood sugar levels in patients undergoing cardiac surgery with the Cardiopulmonary Bypass (CPB) procedure. Materials and Methods: This study is an experimental study with a single-blind randomized controlled design. Patients will be divided into 2 groups consisting of 12 patients each, namely group R (remifentanil) received remifentanil, and group F (fentanyl) received fentanyl. Blood sugar levels will be checked before and after surgery. Results: The research has been conducted at Dr. Hasan Sadikin Hospital Bandung from February 2023 to May 2023. The average increase in blood sugar levels in the remifentanil group was 74 mg/dl, while in the fentanyl group, it was 90 mg/dl. The p-value given is 0.214. Statistical test results showed that the value of p> 0.05. Conclusion: This study concludes that there is no significant difference in the increase in blood sugar levels between the two groups (remifentanil and fentanyl). This can be caused by the use of opioid doses in the lower range and more complex surgical procedures in our research.
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