射血分数保留型心力衰竭(HFpEF)肥胖患者的表型差异--微型综述

Nanni Michelle, Hu Vivian, Patnaik Swagata, Sandoval Alejandro Folch, Contreras Johanna
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引用次数: 0

摘要

射血分数保留型心力衰竭(HFpEF)的发病率持续上升,而肥胖仍然是影响 HFpEF 患者的主要合并症。最近的研究揭示了肥胖在 HFpEF 发病过程中扮演的重要病理生理学角色,为今后了解该病的病因和治疗提供了许多发展机会。对这些病理生理学发展至关重要的是能清楚描述 HFpEF 中肥胖表型特征的研究,并将其与无肥胖患者的 HFpEF 表现进行比较。本文回顾了有关 HFpEF 中肥胖表型的现有文献,并讨论了两种疾病之间病理生理学相互作用背后的一些流行观点,以及可改善 HFpEF 治疗效果的现有治疗方法。
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Phenotypic differences in Obese Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) - A Mini Review
The incidence of heart failure with preserved ejection fraction (HFpEF) continues to rise, and obesity continues to be a predominant comorbid condition affecting patients with HFpEF. Recent research sheds light on the important pathophysiologic role that obesity plays in the development of HFpEF, with many areas of opportunity existing for future developments in understanding the etiology and management of the disease. Crucial in these pathophysiologic developments are studies that clearly characterize the obesity phenotype in HFpEF and compare it to presentations of HFpEF in patients without obesity. This paper reviews the existing literature on the obesity phenotype within HFpEF and discusses some of the prevailing ideas behind the pathophysiologic interplay between the conditions, as well as the existing treatments demonstrating improved outcomes in HFpEF.
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