利用干沉积技术开发 "智能 "金属基质或金属掺杂抗菌表面涂层

Laurène Youssef, Audrey Prorot, Alain Denoirjean, Laurène Gnodé, Thibault Maerten, Canet Acikgoz
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摘要

2019 年底出现的 SARS-CoV-2 病毒震撼了科学界。随后,来自不同领域的研究团队迅速动员起来,寻求充分有效的长期解决方案。然而,病原体不仅限于病毒:细菌是存在于所有环境中的微生物,也有可能引发人类疾病。可能的传播途径之一是通过接触被感染者接触过的物体表面。在这项工作中,利摩日的 IRCER 通过等离子喷涂技术开发出了以 Cu 为抗菌基质的涂层,并在涂层中掺入了光催化剂 TiO2,以评估两种效应对 Cu 杀菌特性的协同作用。与此同时,列支敦士登的 Oerlikon Balzers 公司也提供了通过 PVD 技术制作的带有抗菌掺杂剂(银和铜)的 TiN 涂层。所有抗菌测试都在利摩日的 E2Lim 进行,目的是比较杀菌元素的数量和涂层表面条件对其消灭病原体能力的影响。通过流式细胞仪对细菌的酶活性进行研究的结果将在本论文中公布。
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Development of ‘smart’ metal-matrix or metal-dopant antibacterial surface coatings by dry deposition techniques
The emergence of the SARS-CoV-2 virus in late 2019 shook the scientific community. Research teams from different fields then quickly mobilized to seek adequate and efficient long-term solutions. However, pathogens are not only limited to viruses: bacteria are microorganisms found in all environments and also likely to cause human diseases. One of the possible transmission routes is through contact with surfaces touched by infected people. In this work, coatings with an antibacterial matrix of Cu are developed by plasma spraying at IRCER, Limoges and doped with a photo-catalyst, TiO2, in order to evaluate the synergy of the two effects on the bactericidal character of Cu. In parallel, TiN coatings with antibacterial dopants (Ag and Cu) elaborated by PVD, are supplied by Oerlikon Balzers, Liechtenstein. All antibacterial tests are carried out at E2Lim, Limoges with the aim of comparing on the one hand the effect of the quantity of a bactericidal element and on the other hand the surface condition of the coating on its ability to destroy pathogens. Results of studies by flow cytometry of the bacteria’s enzymatic activity are presented in this work.
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