柠檬酸盐稳定金纳米棒对侵袭性癌细胞的选择性细胞毒性及其治疗黑色素瘤的潜力

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology and Bioprocess Engineering Pub Date : 2024-04-01 DOI:10.1007/s12257-024-00098-2
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引用次数: 0

摘要

摘要 虽然个性化癌症疗法提高了特定癌症类型的治疗效果,但遗传因素不明确的癌症仍然是一个挑战。金纳米棒(GNRs)作为一种癌症疗法备受关注,因为它即使在没有光照射的情况下也具有抗癌效果。本研究探讨了柠檬酸盐稳定的金纳米棒(CGNRs)对黑色素瘤细胞系和肿瘤的抗癌作用,以及影响其疗效的因素。研究发现,CGNRs 对特定的癌细胞具有很强的敏感性,但对正常细胞却不敏感。细胞活力分析表明,CGNRs 能以浓度依赖的方式诱导细胞死亡,其抗癌作用主要是由于细胞坏死。使用小鼠黑色素瘤模型进行的体内实验表明,CGNRs 的瘤内给药能显著抑制肿瘤生长,且不会导致体重减轻。有趣的是,我们的研究结果表明,CGNRs 的抗癌作用与其细胞吸收效率无关,但可能与癌细胞的侵袭性高度相关。总之,研究结果表明,CGNRs 具有治疗黑色素瘤(尤其是侵袭性增殖细胞)的潜力,可作为传统化疗的替代或补充疗法。
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Selective cytotoxicity of citrate-stabilized gold nanorods against aggressive cancer cells and their potential in the melanoma treatment

Abstract

While personalized cancer therapies have improved treatment efficacy for specific cancer types, cancers with unclear genetic factors remain a challenge. Gold nanorods (GNRs) have gained attention as cancer therapies due to their anticancer effects even without light irradiation. This study investigates the anticancer effects of citrate-stabilized gold nanorods (CGNRs) on melanoma cell lines and tumors, as well as the factors influencing their efficacy. The study found that CGNRs exhibited strong sensitivity in specific cancer cells but not in normal cells. Cell viability analysis showed that CGNRs induce cell death in a concentration-dependent manner, and their anticancer effects are mainly due to necrosis. In vivo experiments using a murine melanoma model showed that intratumoral administration of CGNRs significantly suppressed tumor growth without body weight loss. Interestingly, our results suggest that the anticancer effects of CGNRs were independent of their cellular uptake efficiency but may be highly correlated with the aggressiveness of cancer cells. Overall, the results suggest that CGNRs have promising potential as a specific treatment for melanoma, especially for aggressively proliferating cells, and may represent an alternative or complementary therapy to conventional chemotherapy.

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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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