肿瘤血管生成导航:治疗视角与髓细胞调控机制

IF 9.2 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE Angiogenesis Pub Date : 2024-04-06 DOI:10.1007/s10456-024-09913-z
Fan Yang, Gloria Lee, Yi Fan
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引用次数: 0

摘要

持续的血管生成是癌症的标志。错综复杂的肿瘤血管微环境助长了癌症的发展和转移,增强了抗药性,并有助于免疫逃避。针对肿瘤血管的治疗策略已成为癌症治疗的变革,包括抗血管生成、血管正常化和内皮重编程。越来越多的证据表明,巨噬细胞、髓源抑制细胞(MDSCs)和中性粒细胞等浸润性髓系细胞对肿瘤血管生成具有动态调控作用。了解这些调控机制对于成功开展以血管为靶点的癌症治疗至关重要。旨在破坏髓系细胞介导的肿瘤血管生成的治疗干预措施可重塑肿瘤微环境,克服肿瘤对放射/化疗和免疫疗法的耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism

Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and facilitates immune evasion. Therapeutic strategies targeting tumor vasculature have emerged as transformative for cancer treatment, encompassing anti-angiogenesis, vessel normalization, and endothelial reprogramming. Growing evidence suggests the dynamic regulation of tumor angiogenesis by infiltrating myeloid cells, such as macrophages, myeloid-derived suppressor cells (MDSCs), and neutrophils. Understanding these regulatory mechanisms is pivotal in paving the way for successful vasculature-targeted cancer treatments. Therapeutic interventions aimed to disrupt myeloid cell-mediated tumor angiogenesis may reshape tumor microenvironment and overcome tumor resistance to radio/chemotherapy and immunotherapy.

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来源期刊
Angiogenesis
Angiogenesis PERIPHERAL VASCULAR DISEASE-
CiteScore
21.90
自引率
8.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.
期刊最新文献
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis is limited by LIC1-mediated lysosomal trafficking. Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations. Inflammasome activation aggravates choroidal neovascularization. Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
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