异质性与相互作用:癌症相关成纤维细胞在肿瘤中的多方面作用及治疗策略

Qiaoqiao Liu, Fei Yao, Liangliang Wu, Tianyuan Xu, Jintong Na, Zhen Shen, Xiyu Liu, Wei Shi, Yongxiang Zhao, Yuan Liao
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摘要

癌症的发展历程是一个多方面、分阶段的过程。癌症的类型和阶段不同,治疗方法也大相径庭。癌症相关成纤维细胞(CAFs)普遍存在于各种癌症类型和阶段,在肿瘤发生、发展、转移和耐药性方面起着关键作用。同时靶向癌细胞和成纤维细胞的策略在癌症治疗中大有可为。在这篇综述中,我们将重点关注 CAFs,深入研究它们在癌症进展中的关键作用。我们首先探讨了 CAFs 的起源、分类和表面标志物。随后,我们强调了癌细胞与 CAFs 之间相互作用所涉及的关键细胞因子和信号通路,以及它们对肿瘤免疫微环境的影响。此外,我们还探讨了目前针对 CAFs 的治疗方法。本文强调了 CAFs 在肿瘤微环境中的多种作用及其在癌症治疗中的潜在应用,突出了它们作为克服耐药性和提高肿瘤疗法疗效的关键靶点的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Heterogeneity and interplay: the multifaceted role of cancer-associated fibroblasts in the tumor and therapeutic strategies

The journey of cancer development is a multifaceted and staged process. The array of treatments available for cancer varies significantly, dictated by the disease's type and stage. Cancer-associated fibroblasts (CAFs), prevalent across various cancer types and stages, play a pivotal role in tumor genesis, progression, metastasis, and drug resistance. The strategy of concurrently targeting cancer cells and CAFs holds great promise in cancer therapy. In this review, we focus intently on CAFs, delving into their critical role in cancer's progression. We begin by exploring the origins, classification, and surface markers of CAFs. Following this, we emphasize the key cytokines and signaling pathways involved in the interplay between cancer cells and CAFs and their influence on the tumor immune microenvironment. Additionally, we examine current therapeutic approaches targeting CAFs. This article underscores the multifarious roles of CAFs within the tumor microenvironment and their potential applications in cancer treatment, highlighting their importance as key targets in overcoming drug resistance and enhancing the efficacy of tumor therapies.

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