儿科传染病的交叉不平等:瑞典全国队列研究

Samuel Videholm, Sven Arne Silfverdal, Per E Gustafsson
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背景众所周知,社会处境不利的儿童更有可能因感染而住院。但人们对不同的社会不利条件如何相互作用却知之甚少。因此,我们研究了儿童出生后 5 年内在总体感染、上呼吸道感染、下呼吸道感染、肠道感染和泌尿生殖系统感染方面的交叉不平等现象。方法 我们对 1998 年至 2015 年间出生的瑞典儿童进行了一项基于人群的回顾性队列研究。研究采用个体异质性和判别准确性分析作为分析框架,对不平等现象进行了研究。通过综合母亲教育程度、家庭收入、性别和母亲移民身份等信息,创建了一个包含 60 个交叉层的变量。我们使用逻辑回归模型估算了每个交叉层的传染病住院率以及交叉层与传染病住院率之间的关联。此外,我们还量化了交叉阶层对传染病住院率的判别能力。结果 研究共纳入 1785 588 名儿童和 318 080 例住院病例。低学历母亲所生的男孩因感染住院的总体发病率最高,他们生活在家庭收入最低的家庭。在高学历母亲所生的儿童中,感染的总体发生率与家庭收入无关。交叉分层区分感染和未感染儿童的能力较差。结论 我们发现,儿科传染病的不平等是由不同的社会不利因素交叉造成的。这些不平等现象应通过惠及所有儿童的公共卫生政策来解决。数据可能来自第三方,且不对外公开。我们使用了从第三方获得的伪匿名登记数据。其中包括敏感信息,可能会有一些访问限制。感兴趣的研究人员需要直接从瑞典国家卫生与福利委员会(socialstyrelsen@socialstyrelsen.se)和瑞典统计局(scb@scb.se)获取数据。
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Intersectional inequalities in paediatric infectious diseases: a national cohort study in Sweden
Background It is well known that socially deprived children are more likely to be hospitalised for infections. Less is known about how different social disadvantages interact. Therefore, we examine intersectional inequalities in overall, upper respiratory, lower respiratory, enteric and genitourinary infections in the first 5 years of life. Methods We conducted a population-based retrospective cohort study of Swedish children born between 1998 and 2015. Inequalities were examined using analysis of individual heterogeneity and discriminatory accuracy as the analytical framework. A variable with 60 intersectional strata was created by combining information on maternal education, household income, sex/gender and maternal migration status. We estimated the incidence rates of infectious disease hospitalisation for each intersectional strata and the associations between intersectional strata and infectious disease hospitalisations using logistic regression models. We furthermore quantified the discriminatory ability of the intersectional strata with respect to infectious disease hospitalisation. Results The study included 1785 588 children and 318 080 hospital admissions. The highest overall incidence of hospitalisations for infections was found in boys born to low-educated mothers who lived in families with the lowest household income. The overall incidence of infections was unrelated to household income in children born to highly educated mothers. The ability of the intersectional strata to discriminate between children with and without infections was poor. Conclusion We found that inequalities in paediatric infectious diseases were shaped by the intersections of different social disadvantages. These inequalities should be addressed by public health policies that reach all children. Data may be obtained from a third party and are not publicly available. We used pseudo-anonymised register data obtained from third parties. It includes sensitive information and some access restrictions may apply. Interested researchers need to obtain data directly from the National Board of Health and Welfare in Sweden (socialstyrelsen@socialstyrelsen.se) and from Statistics Sweden (scb@scb.se).
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