{"title":"制备叶酸嵌入式胺化药物包封沸石咪唑盐框架，作为治疗肺癌的有效给药系统","authors":"Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mohankumar Ramar, Palanisamy Arulselvan, Sridhar Muthusami","doi":"10.1557/s43578-024-01328-2","DOIUrl":null,"url":null,"abstract":"<p>A novel pH-responsive drug carrier for the delivery of specific Docetaxel (DTX) administration is developed based on a zeolitic imidazolate framework (ZIF-8). Aminating the surface of ZIF-8 is allowed for the conjugation of folic acid (FA). Several spectroscopic studies characterized the newly fabricated DTX-encapsulated folic acid-embedded ethylene diamine (ED) ZIF-8 nanocomposites (DTX/FA@ED-ZIF-8). It has excellent chemical stability and high drug-loading efficiency. DTX from the folic acid-embedded aminated ZIF-8 (FA@ED-ZIF-8) is three-fold more efficient under acidic pH (5.0) than in physiological settings (pH 7.4), according to in vitro drug release tests. DTX/FA@ED-ZIF-8 exhibited cytotoxicity of 76.8% in an MTT experiment conducted in A549 and H1299 cells. Cell morphological and nuclear staining were investigated in the fabricated samples to support the MTT experiments. Further, the apoptosis mode of cell death was examined using Annexin V-FITC and PI by flow cytometry. These findings indicate that FA@ED-ZIF-8 holds great potential as a drug carrier for precise dosing.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":16306,"journal":{"name":"Journal of Materials Research","volume":"2018 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fabrication of folic acid-embedded aminated drug encapsulated zeolitic imidazolate framework as promising drug delivery system for lung cancer\",\"authors\":\"Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mohankumar Ramar, Palanisamy Arulselvan, Sridhar Muthusami\",\"doi\":\"10.1557/s43578-024-01328-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A novel pH-responsive drug carrier for the delivery of specific Docetaxel (DTX) administration is developed based on a zeolitic imidazolate framework (ZIF-8). Aminating the surface of ZIF-8 is allowed for the conjugation of folic acid (FA). Several spectroscopic studies characterized the newly fabricated DTX-encapsulated folic acid-embedded ethylene diamine (ED) ZIF-8 nanocomposites (DTX/FA@ED-ZIF-8). It has excellent chemical stability and high drug-loading efficiency. DTX from the folic acid-embedded aminated ZIF-8 (FA@ED-ZIF-8) is three-fold more efficient under acidic pH (5.0) than in physiological settings (pH 7.4), according to in vitro drug release tests. DTX/FA@ED-ZIF-8 exhibited cytotoxicity of 76.8% in an MTT experiment conducted in A549 and H1299 cells. Cell morphological and nuclear staining were investigated in the fabricated samples to support the MTT experiments. Further, the apoptosis mode of cell death was examined using Annexin V-FITC and PI by flow cytometry. These findings indicate that FA@ED-ZIF-8 holds great potential as a drug carrier for precise dosing.</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical abstract</h3>\\n\",\"PeriodicalId\":16306,\"journal\":{\"name\":\"Journal of Materials Research\",\"volume\":\"2018 1\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1557/s43578-024-01328-2\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1557/s43578-024-01328-2","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Fabrication of folic acid-embedded aminated drug encapsulated zeolitic imidazolate framework as promising drug delivery system for lung cancer
A novel pH-responsive drug carrier for the delivery of specific Docetaxel (DTX) administration is developed based on a zeolitic imidazolate framework (ZIF-8). Aminating the surface of ZIF-8 is allowed for the conjugation of folic acid (FA). Several spectroscopic studies characterized the newly fabricated DTX-encapsulated folic acid-embedded ethylene diamine (ED) ZIF-8 nanocomposites (DTX/FA@ED-ZIF-8). It has excellent chemical stability and high drug-loading efficiency. DTX from the folic acid-embedded aminated ZIF-8 (FA@ED-ZIF-8) is three-fold more efficient under acidic pH (5.0) than in physiological settings (pH 7.4), according to in vitro drug release tests. DTX/FA@ED-ZIF-8 exhibited cytotoxicity of 76.8% in an MTT experiment conducted in A549 and H1299 cells. Cell morphological and nuclear staining were investigated in the fabricated samples to support the MTT experiments. Further, the apoptosis mode of cell death was examined using Annexin V-FITC and PI by flow cytometry. These findings indicate that FA@ED-ZIF-8 holds great potential as a drug carrier for precise dosing.
期刊介绍：
Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome.
• Novel materials discovery
• Electronic, photonic and magnetic materials
• Energy Conversion and storage materials
• New thermal and structural materials
• Soft materials
• Biomaterials and related topics
• Nanoscale science and technology
• Advances in materials characterization methods and techniques
• Computational materials science, modeling and theory
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