The Intensity of Degradation and Synthesis of the Dermal Intercellular Matrix in Rats after Local Cold Injury against the Background of Metabolic Syndrome

Abstract

Research into the processes of tissue regeneration in the postcold period is currently in demand in connection with the development of the Arctic, which is characterized by extremely low temperatures. Metabolic or hormonal abnormalities based on insulin resistance and compensatory hyperinsulinemia, which can promote cardiovascular diseases and, consequently, lead to microcirculatory disorders, are aggravating factors that increase the consequences of cold injuries. In this work, we studied the processes of degradation and synthesis of the dermal intercellular matrix, as well as the concentration of sialic acids in the blood serum after local third-degree cold injury. It was revealed that the regenerative process after local cold damage began on the third day and was characterized by increased content of dermal collagen and thickness of collagen fibers. Regeneration against the background of metabolic syndrome was accompanied by a slowdown in tissue repair processes. The recovery process was accompanied with changed content of sialic acids in the blood serum. A distinctive feature of the dynamics of this indicator was enhanced concentration of sialic acids with metabolic disorders on the seventh day and a slow slight decrease throughout the experiment, which reached control values by the 21st day.