{"title":"[18F]FDG正电子发射计算机断层显像与[68Ga]Ga-FAPI-04正电子发射计算机断层显像在胃癌和胰腺癌诊断中的正面比较：系统综述和荟萃分析","authors":"Wanrun Xie, Bo Li, Zhenzhen Hong, Yi Zhang","doi":"10.1007/s40336-024-00633-4","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Our meta-analysis aimed to compare the positivity rates of [<sup>68</sup>Ga]Ga-FAPI-04 PET and [<sup>18</sup>F]FDG PET in gastric and pancreatic cancer.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We conducted a comprehensive search of PubMed, Embase, and Web of Science databases up to May 2023. The selected studies focused on evaluating the positivity rates of [<sup>18</sup>F]FDG PET and [<sup>68</sup>Ga]Ga-FAPI-04 PET in detecting gastric and pancreatic cancer.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 2,401 studies were screened and 13 articles were finally included. The positivity rates of [<sup>18</sup>F]FDG PET for primary gastric cancer, lymph node and peritoneal metastases were 0.74 [95% confidence interval (CI): 0.55–0.89], 0.49 (95% CI: 0.33–0.65) and 0.52 (95% CI: 0.37–0.67), respectively. On the other hand, [<sup>68</sup>Ga]Ga-FAPI-04 PET demonstrated significantly higher positivity rates at 0.98 (95% CI: 0.92-1.00), 0.76 (95% CI: 0.60–0.89) and 0.99 (95% CI: 0.93-1.00) (<i>P</i> < 0.01,<i>P</i> = 0.02, <i>P</i> < 0.01), respectively. For pancreatic cancer, [<sup>18</sup>F]FDG PET showed positivity rates of 0.93 (95% CI: 0.76-1.00) and 0.46 (95% CI: 0.23–0.69) for primary cancer and lymph node metastases, respectively. In comparison, [<sup>68</sup>Ga]Ga-FAPI-04 PET showed similar positivity rates of 1.00 (95% CI: 0.94-1.00) and 0.68 (95% CI: 0.40–0.90), (<i>P</i> = 0.27, 0.23). There was no significant difference in histopathological positivity rates for signet ring cell carcinoma and TNM stages I and II-IV (<i>P</i> = 0.96, 0.85,0.56).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>[<sup>68</sup>Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [<sup>18</sup>F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [<sup>18</sup>F]FDG PET and [<sup>68</sup>Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"1 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis\",\"authors\":\"Wanrun Xie, Bo Li, Zhenzhen Hong, Yi Zhang\",\"doi\":\"10.1007/s40336-024-00633-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>Our meta-analysis aimed to compare the positivity rates of [<sup>68</sup>Ga]Ga-FAPI-04 PET and [<sup>18</sup>F]FDG PET in gastric and pancreatic cancer.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>We conducted a comprehensive search of PubMed, Embase, and Web of Science databases up to May 2023. The selected studies focused on evaluating the positivity rates of [<sup>18</sup>F]FDG PET and [<sup>68</sup>Ga]Ga-FAPI-04 PET in detecting gastric and pancreatic cancer.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>A total of 2,401 studies were screened and 13 articles were finally included. The positivity rates of [<sup>18</sup>F]FDG PET for primary gastric cancer, lymph node and peritoneal metastases were 0.74 [95% confidence interval (CI): 0.55–0.89], 0.49 (95% CI: 0.33–0.65) and 0.52 (95% CI: 0.37–0.67), respectively. On the other hand, [<sup>68</sup>Ga]Ga-FAPI-04 PET demonstrated significantly higher positivity rates at 0.98 (95% CI: 0.92-1.00), 0.76 (95% CI: 0.60–0.89) and 0.99 (95% CI: 0.93-1.00) (<i>P</i> < 0.01,<i>P</i> = 0.02, <i>P</i> < 0.01), respectively. For pancreatic cancer, [<sup>18</sup>F]FDG PET showed positivity rates of 0.93 (95% CI: 0.76-1.00) and 0.46 (95% CI: 0.23–0.69) for primary cancer and lymph node metastases, respectively. In comparison, [<sup>68</sup>Ga]Ga-FAPI-04 PET showed similar positivity rates of 1.00 (95% CI: 0.94-1.00) and 0.68 (95% CI: 0.40–0.90), (<i>P</i> = 0.27, 0.23). There was no significant difference in histopathological positivity rates for signet ring cell carcinoma and TNM stages I and II-IV (<i>P</i> = 0.96, 0.85,0.56).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>[<sup>68</sup>Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [<sup>18</sup>F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [<sup>18</sup>F]FDG PET and [<sup>68</sup>Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field.</p>\",\"PeriodicalId\":48600,\"journal\":{\"name\":\"Clinical and Translational Imaging\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40336-024-00633-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40336-024-00633-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的我们的荟萃分析旨在比较[68Ga]Ga-FAPI-04 PET和[18F]FDG PET在胃癌和胰腺癌中的阳性率。结果共筛选出 2,401 项研究，最终纳入 13 篇文章。原发性胃癌、淋巴结和腹膜转移的[18F]FDG PET阳性率分别为0.74[95%置信区间（CI）：0.55-0.89]、0.49（95% CI：0.33-0.65）和0.52（95% CI：0.37-0.67）。另一方面，[68Ga]Ga-FAPI-04 PET 的阳性率明显更高，分别为 0.98（95% CI：0.92-1.00）、0.76（95% CI：0.60-0.89）和 0.99（95% CI：0.93-1.00）（P < 0.01,P = 0.02, P < 0.01）。对于胰腺癌，[18F]FDG PET 对原发癌和淋巴结转移的阳性率分别为 0.93（95% CI：0.76-1.00）和 0.46（95% CI：0.23-0.69）。相比之下，[68Ga]Ga-FAPI-04 PET显示的阳性率相似，分别为1.00（95% CI：0.94-1.00）和0.68（95% CI：0.40-0.90）（P = 0.27，0.23）。结论与[18F]FDG PET相比，[68Ga]Ga-FAPI-04 PET在检测原发性胃癌、淋巴结和腹膜转移方面显示出更高的阳性率。对于胰腺癌，[18F]FDG PET 和[68Ga]Ga-FAPI-04 PET 在诊断原发性癌症和检测淋巴结转移方面都表现出相当高的阳性率。这一领域仍需要更广泛和前瞻性的研究。
Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis
Purpose
Our meta-analysis aimed to compare the positivity rates of [68Ga]Ga-FAPI-04 PET and [18F]FDG PET in gastric and pancreatic cancer.
Methods
We conducted a comprehensive search of PubMed, Embase, and Web of Science databases up to May 2023. The selected studies focused on evaluating the positivity rates of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in detecting gastric and pancreatic cancer.
Results
A total of 2,401 studies were screened and 13 articles were finally included. The positivity rates of [18F]FDG PET for primary gastric cancer, lymph node and peritoneal metastases were 0.74 [95% confidence interval (CI): 0.55–0.89], 0.49 (95% CI: 0.33–0.65) and 0.52 (95% CI: 0.37–0.67), respectively. On the other hand, [68Ga]Ga-FAPI-04 PET demonstrated significantly higher positivity rates at 0.98 (95% CI: 0.92-1.00), 0.76 (95% CI: 0.60–0.89) and 0.99 (95% CI: 0.93-1.00) (P < 0.01,P = 0.02, P < 0.01), respectively. For pancreatic cancer, [18F]FDG PET showed positivity rates of 0.93 (95% CI: 0.76-1.00) and 0.46 (95% CI: 0.23–0.69) for primary cancer and lymph node metastases, respectively. In comparison, [68Ga]Ga-FAPI-04 PET showed similar positivity rates of 1.00 (95% CI: 0.94-1.00) and 0.68 (95% CI: 0.40–0.90), (P = 0.27, 0.23). There was no significant difference in histopathological positivity rates for signet ring cell carcinoma and TNM stages I and II-IV (P = 0.96, 0.85,0.56).
Conclusion
[68Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [18F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [18F]FDG PET and [68Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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