葡萄属植物中参与白藜芦醇类芪类化合物生物合成的关键酶:综述

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-04-16 DOI:10.1007/s11101-024-09958-4
Blandine Marant, Jérôme Crouzet, Amandine L. Flourat, Philippe Jeandet, Aziz Aziz, Eric Courot
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引用次数: 0

摘要

多酚是一大类具有有趣生物特性的植物特殊代谢物。其中,白藜芦醇植物毒素在葡萄中的含量尤为丰富,在化妆品和营养保健品行业的应用也相当广泛。经过深入研究的白桦烯生物合成途径利用苯丙氨酸生成白藜芦醇,这是葡萄中合成的主要白桦烯核心。一组酶进一步代谢白藜芦醇,产生具有不同性质、活性和稳定性的多种二苯乙烯。在葡萄藤中,已经发现 13 种酶能够以白藜芦醇为底物,其中包括 10 种过氧化物酶、两种糖基转移酶和一种 O-甲基转移酶。过氧化物酶和甲基转移酶是研究得最多的葡萄酶,尤其是在胁迫条件下。本文概述了葡萄属植物中参与白藜芦醇类衍生物合成的关键酶,讨论了确定新酶的前景,这些新酶可进一步利用生物技术进行二苯乙烯类生物生产。
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Key-enzymes involved in the biosynthesis of resveratrol-based stilbenes in Vitis spp.: a review

Polyphenols are a large class of plant specialized metabolites with interesting biological properties. Among them, the stilbene phytoalexins are particularly abundant in grapevine gaining considerable applications in the cosmetic and nutraceutical industry. The well-studied stilbene biosynthetic pathway uses phenylalanine to generate resveratrol, the primary stilbene core synthetized in grapevine. A set of enzymes further metabolize resveratrol producing a diversity of stilbenes with different properties, activities and stabilities. In grapevine, 13 enzymes have been identified with the ability to use resveratrol as a substrate, including ten peroxidases, two glycosyltransferases and one O-methyltransferase. Peroxidases and methyltransferases are the most studied enzymes in grapevine, especially under stress conditions while the role of plant laccases and hydroxylases in stilbene metabolism is still poorly described. This article provides an overview of the key enzymes involved in the synthesis of resveratrol-based derivatives in Vitis spp. Perspectives to identify new enzymes are discussed, which could be further used for stilbene bioproduction using biotechnologies.

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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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