在啮齿动物疼痛模型中,外周直流电可减少脊髓自然诱发的痛觉活动

IF 3.7 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of neural engineering Pub Date : 2024-04-17 DOI:10.1088/1741-2552/ad3b6c
Tom F Su, Jack D Hamilton, Yiru Guo, Jason R Potas, Mohit N Shivdasani, Gila Moalem-Taylor, Gene Y Fridman, Felix P Aplin
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摘要

目的。电神经调控是治疗慢性疼痛的一种成熟的非药物疗法。然而,现有的脉冲刺激设备通常会间接抑制疼痛通路,并不适用于所有类型的慢性疼痛。直流电(DC)刺激是最近开发的一种技术,它对小直径纤维的影响比脉冲刺激更强。由于痛觉感受器主要是小直径的 Aδ 和 C 纤维,我们研究了能否利用这一特性来优先减少痛觉信号。研究方法我们将直流电波形应用于雌雄大鼠的坐骨神经,并使用与不同感觉模式相对应的各种自然刺激而不是广谱电刺激记录后爪诱发的多单位脊髓活动。为了确定直流电神经调控对不同类型的慢性疼痛是否有效,在神经病理性疼痛和炎症性疼痛模型中进行了测试。主要结果。我们发现,在测试的两种疼痛模型中,直流电的应用都能减少有害刺激引起的反应以及触觉引起的反应,我们认为触觉引起的反应可能与异感症有关。与疼痛模型相比,天真动物不同模式的脊髓活动均有所减少,这表明生理变化(如疾病状态介导的生理变化)在决定神经调控结果方面的作用可能比以前认为的更大。意义重大。我们的研究结果支持直流电神经调控作为一种减少痛觉信号的方法的持续发展,并表明与现有设备相比,直流电神经调控可有效治疗更广泛的异常疼痛病症。
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Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain
Objective. Electrical neuromodulation is an established non-pharmacological treatment for chronic pain. However, existing devices using pulsatile stimulation typically inhibit pain pathways indirectly and are not suitable for all types of chronic pain. Direct current (DC) stimulation is a recently developed technology which affects small-diameter fibres more strongly than pulsatile stimulation. Since nociceptors are predominantly small-diameter Aδ and C fibres, we investigated if this property could be applied to preferentially reduce nociceptive signalling. Approach. We applied a DC waveform to the sciatic nerve in rats of both sexes and recorded multi-unit spinal activity evoked at the hindpaw using various natural stimuli corresponding to different sensory modalities rather than broad-spectrum electrical stimulus. To determine if DC neuromodulation is effective across different types of chronic pain, tests were performed in models of neuropathic and inflammatory pain. Main results. We found that in both pain models tested, DC application reduced responses evoked by noxious stimuli, as well as tactile-evoked responses which we suggest may be involved in allodynia. Different spinal activity of different modalities were reduced in naïve animals compared to the pain models, indicating that physiological changes such as those mediated by disease states could play a larger role than previously thought in determining neuromodulation outcomes. Significance. Our findings support the continued development of DC neuromodulation as a method for reduction of nociceptive signalling, and suggests that it may be effective at treating a broader range of aberrant pain conditions than existing devices.
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来源期刊
Journal of neural engineering
Journal of neural engineering 工程技术-工程:生物医学
CiteScore
7.80
自引率
12.50%
发文量
319
审稿时长
4.2 months
期刊介绍: The goal of Journal of Neural Engineering (JNE) is to act as a forum for the interdisciplinary field of neural engineering where neuroscientists, neurobiologists and engineers can publish their work in one periodical that bridges the gap between neuroscience and engineering. The journal publishes articles in the field of neural engineering at the molecular, cellular and systems levels. The scope of the journal encompasses experimental, computational, theoretical, clinical and applied aspects of: Innovative neurotechnology; Brain-machine (computer) interface; Neural interfacing; Bioelectronic medicines; Neuromodulation; Neural prostheses; Neural control; Neuro-rehabilitation; Neurorobotics; Optical neural engineering; Neural circuits: artificial & biological; Neuromorphic engineering; Neural tissue regeneration; Neural signal processing; Theoretical and computational neuroscience; Systems neuroscience; Translational neuroscience; Neuroimaging.
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