骨细胞对髓外和骨髓脂肪组织发育和功能的调节作用

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2024-04-16 DOI:10.1007/s11914-024-00871-5
Beata Lecka-Czernik, Mohd Parvez Khan, Joshua Letson, Sudipta Baroi, Amit Chougule
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引用次数: 0

摘要

综述目的本综述总结了骨细胞支持髓外和骨髓脂肪细胞发育的证据,并讨论了核受体过氧化物酶体增殖激活受体γ(PPARG)和α(PPARA)的内源性骨细胞活性在这种支持中的作用。它们在调节骨细胞分泌组和骨细胞生物能方面发挥着重要作用;这两项活动部分通过影响髓外脂肪细胞和骨髓脂肪细胞的代谢功能,对全身能量代谢水平做出了贡献。由 PPARs 控制的骨细胞内分泌/旁分泌活动(包括硬骨素的表达)直接调节脂肪细胞的功能,而由 PPARs 控制的骨细胞燃料利用和氧化磷酸化有助于满足骨骼对葡萄糖和脂肪酸的需求,而葡萄糖和脂肪酸的供应受脂肪细胞的控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function

Purpose of Review

This review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role of endogenous osteocyte activities of nuclear receptors peroxisome proliferator-activated receptor gamma (PPARG) and alpha (PPARA) in this support.

Recent Findings

PPARG and PPARA proteins, key regulators of glucose and fatty acid metabolism, are highly expressed in osteocytes. They play significant roles in the regulation of osteocyte secretome and osteocyte bioenergetics; both activities contributing to the levels of systemic energy metabolism in part through an effect on metabolic function of extramedullary and bone marrow adipocytes. The PPARs-controlled osteocyte endocrine/paracrine activities, including sclerostin expression, directly regulate adipocyte function, while the PPARs-controlled osteocyte fuel utilization and oxidative phosphorylation contribute to the skeletal demands for glucose and fatty acids, whose availability is under the control of adipocytes.

Summary

Bone is an inherent element of systemic energy metabolism with PPAR nuclear receptors regulating osteocyte-adipocyte metabolic axes.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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