Sarah Akua Osafo, Precious Osayamen Etinosa, John David Obayemi, Ali Azeko Salifu, Tabiri Asumadu, Desmond Klenam, Benjamin Agyei-Tuffour, David Dodoo-Arhin, Abu Yaya, Winston Oluwole Soboyejo
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引用次数: 0
摘要
尽管 Ti-6Al-4V 具有诱人的细胞/表面相互作用、生物相容性和良好的机械性能,但仍有必要加强与生物医学设备植入人体相关的细胞/表面整合的早期阶段。本文介绍了一种在 Ti-6Al-4V 上进行纳米级和纳米结构羟基磷灰石(HA)涂层的新颖、简便且可重复的方法。结合使用拉曼光谱、扫描电子显微镜和能量色散 X 射线光谱,对得到的纳米级涂层/纳米结构进行了表征。结果表明,纳米结构/纳米级涂层能增强骨细胞(hFOB 细胞)在 Ti-6Al-4V 表面的早期细胞扩散和整合。这些改善包括通过涂层表面的纳米级 HA 结构加速细胞外基质、细胞扩散和增殖。讨论了这些结果对开发医管局纳米结构以改善 Ti-6Al-4V 在整形外科和牙科应用中的骨结合的影响。
Hydroxyapatite nano-pillars on TI-6Al-4V: Enhancements in cell spreading and proliferation during cell/surface integration
Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti-6Al-4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti-6Al-4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scanning electron microscopy equipped with energy dispersive x-ray spectroscopy. The nanostructured/nanoscale coatings are shown to enhance the early stages of cell spreading and integration of bone cells (hFOB cells) on Ti-6Al-4V surfaces. The improvements include the acceleration of extra-cellular matrix, cell spreading and proliferation by nanoscale HA structures on the coated surfaces. The implications of the results are discussed for the development of HA nanostructures for the improved osseointegration of Ti-6Al-4V in orthopedic and dental applications.
期刊介绍:
The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device.
The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials.
Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.