内含子中的循环编码

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-17 DOI:10.1016/j.biosystems.2024.105215
Christian J. Michel
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引用次数: 0

摘要

根据在基因中观察到的循环代码 X 的自相关函数,对(真核生物)内含子进行了大规模统计分析。令人惊讶的是,在鸟类、子囊菌、担子菌、绿藻和陆地植物等 5 组内含子中发现了循环编码周期性 0 modulo 3。这种循环编码周期性是检索(蛋白质编码)基因中阅读框的一种特性,可能表明这些内含子具有编码特性。众所周知,在两栖动物、鱼类、哺乳动物、其他动物、爬行动物和类人猿等 6 组内含子中观察到了 1 模 2 周期性。在昆虫的内含子中发现了模数为 2 和 3 的混合周期。令人惊讶的是,亚周期性 3 modulo 6 是这 3 类内含子的共同统计特性。如果不考虑循环编码 X 的特定三核苷酸 N1N2N1,则在两栖类、鱼类、其他动物、爬行类和昆虫这 5 组内含子中,可以发现被周期性 1 模 2 所掩盖的循环编码周期性 0 模 3。因此,在 12 个内含子组中,有 10 个在分类学上不同,其编码特性与阅读框检索有关。三核苷酸 N1N2N1 在 216 个最大 C3 自互补三核苷酸循环编码中进行了分析。提出了一种六核苷酸代码(由 6 个字母组成的字)来解释 3 模乘 6 的周期性。它可能是更一般的循环码的踪迹,是循环码 X 的起源。
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Circular code in introns

A massive statistical analysis based on the autocorrelation function of the circular code X observed in genes is performed on the (eukaryotic) introns. Surprisingly, a circular code periodicity 0 modulo 3 is identified in 5 groups of introns: birds, ascomycetes, basidiomycetes, green algae and land plants. This circular code periodicity, which is a property of retrieving the reading frame in (protein coding) genes, may suggest that these introns have a coding property. In a well-known way, a periodicity 1 modulo 2 is observed in 6 groups of introns: amphibians, fishes, mammals, other animals, reptiles and apicomplexans. A mixed periodicity modulo 2 and 3 is found in the introns of insects. Astonishing, a subperiodicity 3 modulo 6 is a common statistical property in these 3 classes of introns. When the particular trinucleotides N1N2N1 of the circular code X are not considered, the circular code periodicity 0 modulo 3, hidden by the periodicity 1 modulo 2, is now retrieved in 5 groups of introns: amphibians, fishes, other animals, reptiles and insects. Thus, 10 groups of introns, taxonomically different, out of 12 have a coding property related to the reading frame retrieval. The trinucleotides N1N2N1 are analysed in the 216 maximal C3 self-complementary trinucleotide circular codes. A hexanucleotide code (words of 6 letters) is proposed to explain the periodicity 3 modulo 6. It could be a trace of more general circular codes at the origin of the circular code X.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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