通过单细胞测序揭示腹主动脉瘤中 CD4+ T 细胞的多样性和 Tregs 的组织适应性

IF 4.9 3区 医学 Q2 IMMUNOLOGY Immunology Pub Date : 2024-04-18 DOI:10.1111/imm.13796
Luna Zhai, Wangling Hu, Jingyong Li, Dan Li, Ni Xia, Tingting Tang, Shaofang Nie, Min Zhang, Jiao Jiao, Bingjie Lv, Fen Yang, Yuzhi Lu, Lingfeng Zha, Muyang Gu, Xiajun Hu, Shuang Wen, Desheng Hu, Li Zhang, Weimin Wang, Xiang Cheng
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摘要

免疫细胞浸润是腹主动脉瘤(AAA)的一个重要病理过程。T 细胞,尤其是 CD4+ T 细胞,是造成主动脉大量浸润的重要免疫细胞。AAA 中的调节性 T 细胞(Tregs)已被确定为组织特异性的,但获得组织特异性表型的时间、位置和机制仍不清楚。通过对 AAA 主动脉和脾脏的 CD4+ T 细胞进行单细胞 RNA 测序(scRNA-seq),我们发现了 CD4+ T 细胞的异质性,并鉴定出了活化、增殖和发育的主动脉 Tregs。这些 Tregs 起源于外周组织,并在主动脉中获得组织特异性表型。在 AAA 中发现 Tregs 的前体为了解 AAA 的发病机制提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Unravelling CD4+ T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing

Immune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified activated, proliferating and developed aorta Tregs. These Tregs originate in the peripheral tissues and acquire the tissue-specific phenotype in the aorta. The identification of precursors for Tregs in AAA provides new insight into the pathogenesis of AAA.

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来源期刊
Immunology
Immunology 医学-免疫学
CiteScore
11.90
自引率
1.60%
发文量
175
审稿时长
4-8 weeks
期刊介绍: Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.
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