克隆首只濒危黑脚雪貂以拯救基因

Ben Jacob Novak, Pete Gober, Robyn Bortner, Della Garelle, Mary Wright, Justin Novak, Marlys L Houck, Oliver A Ryder, Dennis Milutinovich, Jill Benavidez, Kerry Ryan, Shawn Walker, Sanaz Sadeghieh Arenivas, Lauren Aston, Blake Russell, Paul Marinari, Adrienne Crosier, Kelly Helmick, Mary R Gibson, Daniel P Carlson, Bradley J Swanson, Samantha M Wisely, Zoe S White, Colleen Lynch, Ryan Phelan
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引用次数: 0

摘要

一只濒临灭绝的黑脚雪貂雌性于 1988 年死亡,目前的种群中没有存活的后代,利用跨物种体细胞核移植技术,从冷冻保存的细胞中成功克隆了这只雌性黑脚雪貂,并培育出了三只健康的黑脚雪貂。这些克隆的后代将为育种计划提供第 8 个创始人,并增加该物种有限基因库的遗传变异。这标志着美国本土濒危物种首次被克隆。
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First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue
An endangered black-footed ferret female that died in 1988 with no living descendants in the current population was successfully cloned from cryopreserved cells using cross-species somatic cell nuclear transfer, producing three healthy kits. Incorporating progeny from these clones would provide an 8th founder to the breeding program and increase genetic variation to the species' limited gene-pool. This marks the first time a native U.S. endangered species has been cloned.
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