香叶醇和柠檬醛:其抗癌功效的最新进展为癌症辅助疗法开辟了新天地

Gauri Srivastava, Esha Mukherjee, Ruchika Mittal, Deepak Ganjewala
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摘要

每年约有 1 000 万人被诊断出患有癌症。在全球范围内,癌症是仅次于心脏病的第二大死因,到 2035 年,死亡人数可能达到 1 460 万。目前已有多种治疗癌症的药物和疗法,但存活率仍然很低。近年来的许多研究表明,从植物中提取的单萜烯类化合物,尤其是香叶醇和柠檬醛,对各种癌症有效,包括乳腺癌、肝癌、黑色素瘤、子宫内膜癌、结肠癌、前列腺癌和皮肤癌。这一趋势为开发癌症治疗领域的新疗法或辅助剂提供了新的可能性。这些单萜可以通过调节肿瘤内的多种信号分子和通路来提高化疗的疗效。通过对过去 5 年发表的抗癌效果报告进行分析,我们可以大致了解这些特性和相关特性的最重要结果。此外,还解释了这些药物在细胞和动物研究中发挥抗癌作用的分子机制。因此,本综述旨在强调香叶醇和柠檬醛作为癌症治疗的补充或替代疗法的范围。
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Geraniol and citral: recent developments in their anticancer credentials opening new vistas in complementary cancer therapy
About 10 million people are diagnosed with cancer each year. Globally, it is the second leading cause of death after heart disease, and by 2035, the death toll could reach 14.6 million. Several drugs and treatments are available to treat cancer, but survival rates remain low. Many studies in recent years have shown that plant-derived monoterpenes, particularly geraniol and citral, are effective against various cancers, including breast, liver, melanoma, endometrial, colon, prostate, and skin cancers. This trend has opened new possibilities for the development of new therapeutics or adjuvants in the field of cancer therapy. These monoterpenes can improve the efficacy of chemotherapy by modulating many signaling molecules and pathways within tumors. Analysis of reports on the anticancer effects published in the past 5 years provided an overview of the most important results of these and related properties. Also, the molecular mechanisms by which they exert their anticancer effects in cell and animal studies have been explained. Therefore, this review aims to highlight the scope of geraniol and citral as complementary or alternative treatment options in cancer therapy.
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