{"title":"用于治疗药物监测的超灵敏电化学（生物）传感器","authors":"M. David , M. Florescu","doi":"10.1016/j.coelec.2024.101501","DOIUrl":null,"url":null,"abstract":"<div><p>Ultrasensitive detection is important for the individualized management of medical therapy, playing a key role for the improvement of life expectancy and quality of life. Implementing personalized medicine represents a complex challenge since it requires the development of new, simple, versatile, and sustainable technologies that offer real-time, accurate, and reliable outputs. With increasing chronic conditions and cancers, as well as excessive use and abuse of medication, there is a strong need for continuous monitoring of therapeutic drugs to prevent toxicity levels in cases of overdose or inefficiency in cases of underdose.</p><p>However, to date, only a few easy-to-use monitoring systems are available for trace analysis of therapeutic drugs to help physicians and patients with therapeutic drug monitoring. Here, we critically evaluate recent advances, highlighting the position of electrochemical (bio)sensors on the roadmap towards ultrasensitive detection for personalized therapy.</p></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451910324000620/pdfft?md5=02fe21eb9892c04f0832a2e719fed390&pid=1-s2.0-S2451910324000620-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Ultrasensitive electrochemical (bio)sensors for therapeutic drug monitoring\",\"authors\":\"M. David , M. Florescu\",\"doi\":\"10.1016/j.coelec.2024.101501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ultrasensitive detection is important for the individualized management of medical therapy, playing a key role for the improvement of life expectancy and quality of life. Implementing personalized medicine represents a complex challenge since it requires the development of new, simple, versatile, and sustainable technologies that offer real-time, accurate, and reliable outputs. With increasing chronic conditions and cancers, as well as excessive use and abuse of medication, there is a strong need for continuous monitoring of therapeutic drugs to prevent toxicity levels in cases of overdose or inefficiency in cases of underdose.</p><p>However, to date, only a few easy-to-use monitoring systems are available for trace analysis of therapeutic drugs to help physicians and patients with therapeutic drug monitoring. Here, we critically evaluate recent advances, highlighting the position of electrochemical (bio)sensors on the roadmap towards ultrasensitive detection for personalized therapy.</p></div>\",\"PeriodicalId\":11028,\"journal\":{\"name\":\"Current Opinion in Electrochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2451910324000620/pdfft?md5=02fe21eb9892c04f0832a2e719fed390&pid=1-s2.0-S2451910324000620-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Electrochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451910324000620\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Electrochemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451910324000620","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Ultrasensitive electrochemical (bio)sensors for therapeutic drug monitoring
Ultrasensitive detection is important for the individualized management of medical therapy, playing a key role for the improvement of life expectancy and quality of life. Implementing personalized medicine represents a complex challenge since it requires the development of new, simple, versatile, and sustainable technologies that offer real-time, accurate, and reliable outputs. With increasing chronic conditions and cancers, as well as excessive use and abuse of medication, there is a strong need for continuous monitoring of therapeutic drugs to prevent toxicity levels in cases of overdose or inefficiency in cases of underdose.
However, to date, only a few easy-to-use monitoring systems are available for trace analysis of therapeutic drugs to help physicians and patients with therapeutic drug monitoring. Here, we critically evaluate recent advances, highlighting the position of electrochemical (bio)sensors on the roadmap towards ultrasensitive detection for personalized therapy.
期刊介绍：
The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner:
1.The views of experts on current advances in electrochemistry in a clear and readable form.
2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle:
• Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •
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