来自 AACR 2024

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-04-25 DOI:10.1038/s41571-024-00897-9
Diana Romero
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引用次数: 0

摘要

美国癌症研究协会(American Association for Cancer Research,AACR)2024 年年会汇聚了约 22,000 名代表,他们有的在圣地亚哥,有的通过网络参加会议。正如项目委员会主席在开幕全体会议上所解释的,本次会议的主要目标之一是强调如何将过去十年的技术进步与患者护理相结合。在 I/II 期 LINKER-MM1 试验中,多发性骨髓瘤患者接受了 BCMA × CD3 T 细胞吞噬剂 linvoseltamab 的治疗。客观反应率(ORR)为71%,其中46%的患者有完全反应。虽然73%的患者出现了3-4级感染,但6个月后感染的频率和严重程度都有所下降。在III期COMPASSION-15试验中,胃腺癌和胃食管腺癌患者在一线化疗的基础上加用PD-1 × CTLA4双特异性抗体卡多尼单抗可提高中位总生存期(15个月对10.8个月;HR 0.62,95% CI 0.50-0.78;P < 0.001)。66%的患者出现了≥3级不良反应。在I/II期PETRA试验中,新型聚(ADP核糖)聚合酶1选择性抑制剂saruparib在晚期实体瘤患者中的耐受性良好。发现了一些疗效信号,包括乳腺癌患者的 ORR 为 48%,但还需要更长时间的随访。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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