Ronaldo Lira-Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci
{"title":"间歇性禁食对牙周炎症和龈下微生物群的影响","authors":"Ronaldo Lira-Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci","doi":"10.1002/JPER.23-0676","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (<i>n</i> = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (<i>p</i> < 0.05). Moreover, significant reductions were observed in bleeding on probing (<i>p</i> = 0.01) and the presence of shallow periodontal pockets after fasting (<i>p</i> < 0.001), while no significant change was seen in plaque index (<i>p</i> = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (<i>p</i> > 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4–5 mm compared to those with <60% reduction (bad responders).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.</p>\n </section>\n </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0676","citationCount":"0","resultStr":"{\"title\":\"Effects of intermittent fasting on periodontal inflammation and subgingival microbiota\",\"authors\":\"Ronaldo Lira-Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci\",\"doi\":\"10.1002/JPER.23-0676\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (<i>n</i> = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (<i>p</i> < 0.05). Moreover, significant reductions were observed in bleeding on probing (<i>p</i> = 0.01) and the presence of shallow periodontal pockets after fasting (<i>p</i> < 0.001), while no significant change was seen in plaque index (<i>p</i> = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (<i>p</i> > 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4–5 mm compared to those with <60% reduction (bad responders).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16716,\"journal\":{\"name\":\"Journal of periodontology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0676\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of periodontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/JPER.23-0676\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/JPER.23-0676","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Effects of intermittent fasting on periodontal inflammation and subgingival microbiota
Background
Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota.
Methods
This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.
Results
After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (p < 0.05). Moreover, significant reductions were observed in bleeding on probing (p = 0.01) and the presence of shallow periodontal pockets after fasting (p < 0.001), while no significant change was seen in plaque index (p = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (p > 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4–5 mm compared to those with <60% reduction (bad responders).
Conclusion
Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.