间歇性禁食对牙周炎症和龈下微生物群的影响

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of periodontology Pub Date : 2024-04-24 DOI:10.1002/JPER.23-0676
Ronaldo Lira-Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci
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引用次数: 0

摘要

背景有关间歇性禁食对牙周健康影响的研究仍然很少。因此,本研究评估了长期间歇性禁食对牙周健康和龈下微生物群的影响。方法本试验研究是非随机对照试验的一部分。超重/肥胖参与者(n = 14)参加了一项间歇性禁食计划,特别是 5:2 饮食计划,在该计划中,他们将热量摄入限制在正常日总热量消耗的四分之一左右,连续两天/周。受试者在基线期和开始节食 6 个月后接受了全面的临床和实验室检查,包括牙周状况评估。结果间歇性禁食 6 个月后,受试者的体重、体重指数、C 反应蛋白、血红蛋白 A1c (HbA1c) 和胆固醇含量均有显著改善(p < 0.05)。此外,在禁食后,探诊出血(p = 0.01)和牙周浅袋(p < 0.001)明显减少,而牙菌斑指数没有明显变化(p = 0.14)。虽然我们没有观察到与饮食干预有关的龈下微生物群的α或β多样性的显著变化(p >0.05),但与探查袋深度减少 60% 的个体(良好响应者)相比,探查袋深度减少 4-5 mm 的个体(不良响应者)在几个类群的丰度上存在显著差异。虽然龈下微生物群未因这一干预措施而发生改变,但在良好反应者和不良反应者之间观察到了明显的分类差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effects of intermittent fasting on periodontal inflammation and subgingival microbiota

Background

Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota.

Methods

This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing.

Results

After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (p < 0.05). Moreover, significant reductions were observed in bleeding on probing (p = 0.01) and the presence of shallow periodontal pockets after fasting (p < 0.001), while no significant change was seen in plaque index (p = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (p > 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4–5 mm compared to those with <60% reduction (bad responders).

Conclusion

Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
期刊最新文献
Appraising the life-course impact of Epstein-Barr virus exposure and its genetic signature on periodontitis. Effectiveness of nonsurgical re‐instrumentation: Tooth‐related factors ISSUE INFORMATION Gingival inflammation and leukocyte-endothelium cell interactions in women with polycystic ovary syndrome. Clinical outcomes of using operating microscope for alveolar ridge preservation: A randomized controlled trial.
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