外周定量计算机断层扫描是跟踪骨骼肌横截面积变化的有效成像技术。

IF 1.3 4区 医学 Q4 PHYSIOLOGY Clinical Physiology and Functional Imaging Pub Date : 2024-04-26 DOI:10.1111/cpf.12885
Bradley A. Ruple, Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Joshua S. Godwin, Petey W. Mumford, Matt S. Stock, Michael D. Roberts, Kaelin C. Young
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引用次数: 0

摘要

外周定量计算机断层扫描(pQCT)最近已扩展到骨骼肌的定量分析,但与磁共振成像(MRI)相比,它在确定肌肉横截面积(mCSA)方面的有效性尚不清楚。11 名男性参与者(年龄:22 ± 3 岁)在 6 周阻力训练之前(PRE)和之后(POST)分别接受了 pQCT 和 MRI 双腿大腿中部成像,以量化大腿中部 mCSA 和 mCSA 的变化。阻力训练 6 周后,pQCT 和 MRI mCSA 均有所增加(∆mCSApQCT:6.7 ± 5.4 cm2,p < 0.001;∆mCSAMRI:6.0 ± 6.4 cm2,p < 0.001)。重要的是,mCSA 的变化在不同方法之间没有差异(p = 0.39)。Bland-Altman分析显示,在比较单个时间点的图像时,pQCT相对于MRI倾向于高估mCSA,平均偏差较小(1.10 cm2,LOA:-6.09,8.29 cm2)。pQCT 和 MRI mCSA 在前和后的一致性非常好,CCC 为 0.982。在检测 mCSA 的变化方面,Bland-Altman 分析显示 pQCT 和 MRI 的一致性极佳(平均偏差:-0.73 平方厘米,LOA:-8.37,6.91 平方厘米)。最后,pQCT 和 MRI mCSA 变化评分之间的一致性非常好(CCC = 0.779)。与核磁共振成像相比,pQCT 成像是一种有效的技术,既能测量单个时间点的大腿中部 mCSA,也能测量阻力训练干预后的 mCSA 变化。
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Peripheral quantitative computed tomography is a valid imaging technique for tracking changes in skeletal muscle cross-sectional area

Peripheral quantitative computed tomography (pQCT) has recently expanded to quantifying skeletal muscle, however its validity to determine muscle cross-sectional area (mCSA) compared to magnetic resonance imaging (MRI) is unknown. Eleven male participants (age: 22 ± 3 y) underwent pQCT and MRI dual-leg mid-thigh imaging before (PRE) and after (POST) 6 weeks of resistance training for quantification of mid-thigh mCSA and change in mCSA. mCSA agreement at both time points and absolute change in mCSA across time was assessed using Bland-Altman plots for mean bias and 95% limits of agreement (LOA), as well as Lin's concordance correlation coefficients (CCC). Both pQCT and MRI mCSA increased following 6 weeks of resistance training (∆mCSApQCT: 6.7 ± 5.4 cm2, p < 0.001; ∆mCSAMRI: 6.0 ± 6.4 cm2, p < 0.001). Importantly, the change in mCSA was not different between methods (p = 0.39). Bland-Altman analysis revealed a small mean bias (1.10 cm2, LOA: −6.09, 8.29 cm2) where pQCT tended to overestimate mCSA relative to MRI when comparing images at a single time point. Concordance between pQCT and MRI mCSA at PRE and POST was excellent yielding a CCC of 0.982. For detecting changes in mCSA, Bland-Altman analysis revealed excellent agreement between pQCT and MRI (mean bias: −0.73 cm2, LOA: −8.37, 6.91 cm2). Finally, there was excellent concordance between pQCT and MRI mCSA change scores (CCC = 0.779). Relative to MRI, pQCT imaging is a valid technique for measuring both mid-thigh mCSA at a single time point and mCSA changes following a resistance training intervention.

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来源期刊
CiteScore
3.40
自引率
5.60%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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