从白术中提取的两种新的酯萜类化合物（Atractylodes japonica Koidz.

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2024-04-25 DOI:10.1007/s11418-024-01793-3

Yuan-Yuan Zhou, Zhao Sun, Yan Liu, Zhen-Xing Fang, Hui-Rui Gao, Ning-Yu Liu, Xiao-Juan Zhang, Bing-You Yang, Hai-Xue Kuang

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引用次数: 0

摘要

从白术根茎中分离出两种新的酯萜类化合物，即白术萜酸 I（1）和白术萜醛 I（2），以及 10 种已知化合物（3-12）。通过全面的光谱分析（1D/2D NMR、HRESIMS 和 IR），阐明了这些化合物的结构。此外，还评估了所有这些分离化合物对人胃癌细胞 MGC-803 和人肝癌细胞 HepG-2 的细胞毒活性。除 9-12 号化合物外，大多数化合物都表现出中等至弱的抑制作用，IC50 值在 25.15-88.85 μM 之间。

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Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam

Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3–12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC₅₀ values in the range of 25.15–88.85 μM except for 9–12.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.