黄芩苷通过 TGF-β1 信号通路改善糖尿病肾病

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-04-24 DOI:10.1007/s13659-024-00446-y

Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi

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摘要

蒲公英是一种天然黄酮类混合物，提取自传统中草药麦冬（Erigeron breviscapus (Vant.) Hand-Mazz），在改善糖尿病肾病（DN）方面具有良好的潜力。然而，导致其治疗效果的特定活性成分及其药理机制仍不清楚。在这项研究中，我们旨在研究黄芩苷（breviscapine 的一种成分）对链脲佐菌素诱导的糖尿病肾病的影响，并阐明其药理机制。我们的研究结果表明，黄芩苷能有效改善体内糖尿病肾病的各种特征，包括蛋白尿、肾小球扩张、系膜基质堆积、肾脏纤维化和荚膜细胞损伤。从机理上讲，黄芩苷似乎是通过调节转化生长因子-β1（TGF-β1）信号通路及其与细胞外信号调节激酶（Erk）和Wnt/β-catenin通路的相互作用来发挥其有益作用的。

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Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway

Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin-induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.