Melissa officinalis 对癌症患者化疗引起的周围神经病变的影响:随机试验

Zohreh Ehsani, E. Salehifar, Emran Habibi, Reza Alizadeh-Navaei, Mahmoud Moosazadeh, Nasim Tabrizi, E. Zaboli, Versa Omrani-Nava, R. Shekarriz
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摘要

背景:化疗引起的周围神经病变(CIPN)是一种严重的癌症治疗副作用,会影响患者的生活质量和疗程。Melissa Officinalis(MO)含有大量黄酮类化合物,具有抗氧化、抗炎和保护神经的作用。 材料与方法:被诊断为 CIPN 的癌症患者就诊于伊朗萨里的一家转诊中心。采用浸渍法提取 MO 叶子的水醇提取物。对照组接受安慰剂和加巴喷丁作为标准治疗,干预组接受 500 毫克毛果芸香碱和加巴喷丁治疗,每日 2 次,连续 3 个月。根据不良反应通用术语标准(CTCAE)和 EORTC QLQ-C30(生活质量评估综合系统)对患者进行基线和 3 个月后的评估。 结果共有 40 名患者被视为 D 组(干预组),其中 35 名患者完成了研究。在安慰剂组(P)的 40 名受试者中,有 3 名患者因胃肠道不适而无法耐受药物。CTCAE 的最终值显示出显著的统计学差异(P=0.010)。两组患者的生活质量相关指标均有显著改善。干预组的疼痛感和腹泻症状明显减轻。结论服用加巴喷丁和不服用香蜂花都能改善生活质量指标。在化疗方案中添加香蜂草可改善腹泻和疼痛感。
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Effect of Melissa officinalis on Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Randomized Trial
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant cancer treatment side effect that can influence both quality of life and treatment course. Melissa Officinalis (MO), due to its high content of flavonoids, has antioxidant, anti-inflammatory, and neuroprotective properties.  Materials and Methods: The cancer patients diagnosed with CIPN attended a referral center in Sari (Iran). The hydroalcoholic extract of MO leaves was extracted by the maceration method. The control group received a placebo along with gabapentin as the standard treatment, and the intervention group received 500 mg Melissa officinalis 2 times daily for 3 months plus gabapentin. Patients were evaluated at the baseline and 3 months later, according to Common Terminology Criteria for Adverse Effects (CTCAE) and EORTC QLQ-C30 (Integrated System for Quality of Life Assessment).  Results: A total of 40 patients were considered as group D (intervention group), and 35 patients completed the study. Out of 40 subjects in the placebo group (P), 3 patients could not tolerate the drug due to gastrointestinal disturbances. The final values of CTCAE showed a statistically significant difference (p=0.010). Indicators related to the quality of life in both groups showed a significant improvement. In the intervention group, the pain perception and diarrhea experience were significantly reduced. Conclusion: Quality of life indicators were improved by prescribing gabapentin with and without Melissa officinalis. The addition of Melissa officinalis to the chemotherapy regimen may improve diarrhea and pain perception. 
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