大麻对肺部传染病免疫效力的影响。

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-04-19 DOI:10.1515/jbcpp-2023-0030
Sumana Das, Arya Ghosh, Varnita Karmakar, Sourav Khawas, Piyush Vatsha, Kishor Kumar Roy, Padma Charan Behera
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引用次数: 0

摘要

呼吸系统疾病及其影响在全世界越来越普遍。有必要研究创新的治疗和预防技术。在过去两年中,COVID-19疫情造成数百万确诊病例和死亡。根据审查研究,大麻素是一类应考虑用于治疗呼吸系统疾病的药物。大麻素和内源性大麻素降解抑制剂在大量研究(体外和体内)中显示出了抗炎、治疗哮喘、肺纤维化和肺动脉低血压的优势。还有研究指出,巨噬细胞和 T 辅助细胞上的 CB2 受体可能会被特别触发,从而降低 COVID-19 患者的炎症反应。由于大部分肺组织都含有大麻素受体,大麻可以成为治疗 COVID-19 和肺部感染的有效医疗工具。值得注意的是,CB2 和 CB1 受体在免疫系统调节和抗炎活动中发挥着重要作用。在这篇综述中,我们提出了大麻可能有助于治疗由病毒整合引起的肺部感染的观点,例如由 SARS-CoV-2、乙型流感嗜血杆菌、肺炎链球菌、流感病毒和呼吸道合胞病毒引起的肺部感染。此外,CB 受体的详细概述、复杂机制、与 COVID-19 病毒结构修饰的联系以及 CB 受体在减少肺部疾病病毒载量方面的分子基础都得到了文献研究的支持。此外,通过以体内/体外系统为重点的新型制剂开发,对大麻药效进行的未来评估将产生可喜的成果。
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Cannabis effectiveness on immunologic potency of pulmonary contagion.
Respiratory illnesses and its repercussions are becoming more prevalent worldwide. It is necessary to research both innovative treatment and preventative techniques. Millions of confirmed cases and fatalities from the COVID-19 epidemic occurred over the previous two years. According to the review research, cannabinoids are a class of medicines that should be considered for the treatment of respiratory conditions. Cannabinoids and inhibitors of endocannabinoid degradation have illustrated advantageous anti-inflammatory, asthma, pulmonary fibrosis, and pulmonary artery hypotension in numerous studies (in vitro and in vivo). It has been also noted that CB2 receptors on macrophages and T-helper cells may be particularly triggered to lower inflammation in COVID-19 patients. Since the majority of lung tissue contains cannabinoid receptors, cannabis can be an effective medical tool for treating COVID-19 as well as pulmonary infections. Notably, CB2 and CB1 receptors play a major role in immune system modulation and anti-inflammatory activities. In this review, we put forth the idea that cannabis might be helpful in treating pulmonary contagion brought on by viral integration, such as that caused by SARS-CoV-2, haemophilus influenza type b, Streptococcus pneumoniae, influenza virus, and respiratory syncytial virus. Also, a detailed overview of CB receptors, intricate mechanisms, is highlighted connecting link with COVID-19 viral structural modifications along with molecular basis of CB receptors in diminishing viral load in pulmonary disorders supported through evident literature studies. Further, futuristic evaluations on cannabis potency through novel formulation development focusing on in vivo/in vitro systems can produce promising results.
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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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