左旋精氨酸在妊娠期及以后的应用:一种新兴的药物基因组学方法。

IF 3.8 4区 医学 Q2 GENETICS & HEREDITY Current gene therapy Pub Date : 2024-04-19 DOI:10.2174/0115665232262213240329034826
Sai Vaishnavi V, Mahadevamma Lingaiah, Bala Murali Mohan Sanku, Sunil Kumar Kadri, M. K. Mudigubba
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引用次数: 0

摘要

L- 精氨酸是一种半必需氨基酸,在蛋白质合成、伤口愈合、免疫功能和心血管调节等多种生理过程中发挥着关键作用。在妊娠期使用 L-精氨酸一直是药物基因组学领域的一个新兴话题。L- 精氨酸是一种氨基酸,在一氧化氮的产生过程中起着至关重要的作用,而一氧化氮是胎盘正常发育和胎儿生长所必需的。研究表明,孕期补充 L-精氨酸对胎儿生长、孕妇血压和预防子痫前期有积极作用。这种新兴的药物基因组学方法是利用基因信息,根据孕妇的具体基因构成,为其个性化定制左旋精氨酸的剂量。通过这种方法,有可能优化孕期补充左旋精氨酸的益处并改善妊娠结局。本文强调了左旋精氨酸在孕期的潜在应用,以及利用药物基因组学方法提高其有效性。尽管如此,新出现的应用 L-精氨酸的药物基因组学方法为开发治疗各种疾病的新型疗法提供了令人兴奋的前景。
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Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach.
L-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positive effects on fetal growth, maternal blood pressure, and the prevention of preeclampsia. This emerging pharmacogenomic approach involves using genetic information to personalize L-arginine dosages for pregnant women based on their specific genetic makeup. By doing so, it may be possible to optimize the benefits of L-arginine supplementation during pregnancy and improve pregnancy outcomes. This paper emphasizes the potential applications of L-arginine in pregnancy and the use of pharmacogenomic approaches to enhance its effectiveness. Nonetheless, the emerging pharmacogenomic approach to the application of L-arginine offers exciting prospects for the development of novel therapies for a wide range of diseases.
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来源期刊
Current gene therapy
Current gene therapy 医学-遗传学
CiteScore
6.70
自引率
2.80%
发文量
46
期刊介绍: Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.
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