败血症患者的免疫纠正(文献综述)

A. V. Stepanov, K. G. Shapovalov
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引用次数: 0

摘要

有关该出版物的国内出版物可在 RSCI 网站的数据库中搜索,国外出版物可在 PubMed 和 Google Scholar 数据库中搜索,搜索时间为 2022 年至 2023 年。他们的分析表明,目前积极研究的败血症免疫纠正方法旨在改变细胞因子、生长因子的含量或活性,使用免疫检查点抑制剂以及髓系抑制细胞。在调节细胞因子的作用时,使用了多种方法,如改变细胞因子与其受体的亲和力、延长细胞因子的半衰期和 "微调 "细胞因子的作用。为了安全有效地使用生物调节剂对脓毒症进行免疫校正,需要对其临床效果进行更多的多中心研究,包括考虑将患者分为不同的内型和生物调节剂的作用机制。
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Immune correction in patients with sepsis (literature review)
The search for domestic publications on this publication was conducted in the database on the RSCI website, and foreign ones in the PubMed and Google Scholar databases in the period 2022-2023. Their analysis showed that actively studied approaches to the immunocorrection of sepsis are aimed at changing the content or activity of cytokines, growth factors, the use of immune checkpoint inhibitors, as well as myeloid suppressor cells. When modulating the action of cytokines, a variety of approaches are used, such as changing the affinity of cytokines to their receptors, extending the half-life of cytokines and «fine-tuning» the action of cytokines. For the safe and effective use of bioregulators for immunocorrection in sepsis, additional multicenter studies of their clinical effectiveness are needed, including taking into account the stratification of patients into individual endotypes and the mechanisms of action of bioregulators.
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