{"title":"铝的毒物动力学--对一种古老佐剂的新认识","authors":"Karin Weisser","doi":"10.1007/s40629-024-00288-7","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>In 2015, an interdisciplinary project was started to fill the gap of knowledge on the toxicokinetics of aluminium (Al) after exposure from adjuvanted products for subcutaneous immunotherapy (SCIT).</p><h3>Methods</h3><p>Two complementary initiatives of the project are explained. The results of two studies are reviewed and put in connection with the overarching goal. An estimate is given which steps have been reached and which are still needed.</p><h3>Results</h3><p>Recent in vivo data provided evidence of systemically available Al from SCIT products in rats (Weisser et al. 2020 [1]). The data are highly valuable for further development of the physiology-based toxicokinetic (PBTK) model for Al exposure which has been established in parallel (Hethey et al. 2021 [2]).</p><h3>Conclusion</h3><p>The Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 8","pages":"304 - 308"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00288-7.pdf","citationCount":"0","resultStr":"{\"title\":\"Toxicokinetics of aluminium—novel insights in an old adjuvant\",\"authors\":\"Karin Weisser\",\"doi\":\"10.1007/s40629-024-00288-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>In 2015, an interdisciplinary project was started to fill the gap of knowledge on the toxicokinetics of aluminium (Al) after exposure from adjuvanted products for subcutaneous immunotherapy (SCIT).</p><h3>Methods</h3><p>Two complementary initiatives of the project are explained. The results of two studies are reviewed and put in connection with the overarching goal. An estimate is given which steps have been reached and which are still needed.</p><h3>Results</h3><p>Recent in vivo data provided evidence of systemically available Al from SCIT products in rats (Weisser et al. 2020 [1]). The data are highly valuable for further development of the physiology-based toxicokinetic (PBTK) model for Al exposure which has been established in parallel (Hethey et al. 2021 [2]).</p><h3>Conclusion</h3><p>The Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted.</p></div>\",\"PeriodicalId\":37457,\"journal\":{\"name\":\"Allergo Journal International\",\"volume\":\"33 8\",\"pages\":\"304 - 308\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40629-024-00288-7.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergo Journal International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40629-024-00288-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergo Journal International","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40629-024-00288-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Toxicokinetics of aluminium—novel insights in an old adjuvant
Purpose
In 2015, an interdisciplinary project was started to fill the gap of knowledge on the toxicokinetics of aluminium (Al) after exposure from adjuvanted products for subcutaneous immunotherapy (SCIT).
Methods
Two complementary initiatives of the project are explained. The results of two studies are reviewed and put in connection with the overarching goal. An estimate is given which steps have been reached and which are still needed.
Results
Recent in vivo data provided evidence of systemically available Al from SCIT products in rats (Weisser et al. 2020 [1]). The data are highly valuable for further development of the physiology-based toxicokinetic (PBTK) model for Al exposure which has been established in parallel (Hethey et al. 2021 [2]).
Conclusion
The Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted.
期刊介绍：
Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies.
All submissions are reviewed in single-blind fashion by at least two reviewers.
Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.
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