卵巢大面积水肿和纤维瘤病:罕见病例报告

Thanka Johnson, Abhishri Lakshmi K
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摘要

由纺锤形细胞组成的卵巢病变是一个异质性群体;大多数是肿瘤性的,但也有几种非肿瘤性病变可能由纺锤形细胞组成,包括大量水肿和纤维瘤病以及卵巢纤维瘤。57 岁的绝经后女性,因腹痛、呕吐和便秘就诊。计算机断层扫描显示卵巢扭转。患者接受了分期开腹手术,子宫切除术和双侧输卵管切除术的标本被送去进行组织病理学检查。右侧卵巢切片显示纺锤形细胞增生,类似基质成纤维细胞,并伴有大面积水肿和出血。马森三色染色显示胶原沉积增加。管壁还显示出继发于扭转的变化。根据上述特征,我们做出了卵巢良性纺锤形细胞病变的诊断,鉴别诊断包括卵巢大面积水肿、纤维瘤病和纤维瘤。我们要求对抑制素进行 IHC 检测,结果呈阴性。这证实了大块水肿和纤维瘤病的诊断。
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Massive edema and fibromatosis of ovary: A rare case report
Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic, but several non-neoplastic lesions may be composed of spindle cells, including massive edema and fibromatosis and ovarian fibroma. Herein we discuss both these non- neoplastic entities as a differential diagnosis for our case of benign spindle cell lesion of ovary.57-year-old post-menopausal female presented with abdominal pain, vomiting, constipation. Computed tomography showed, features of ovarian torsion. Staging laparotomy was done and a specimen of hysterectomy with bilateral salpingoophorectomy, was sent for histopathological examination. Sections from right ovary showed proliferation of spindle cells resembling stromal fibroblasts with large areas of edema and haemorrhage. Masson's trichrome show increased collagen deposition. The tube also shows changes secondary to torsion in the wall. Based on the above features, we made a diagnosis of benign spindle cell lesion of ovary with the differential diagnosis including massive edema and fibromatosis and fibroma of ovary. IHC for Inhibin was ordered which came negative. This confirmed the diagnosis of massive edema and fibromatosis.
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