骨髓增生异常综合征/骨髓增生性肿瘤患者外周血涂片诊断为侵袭性念珠菌病:病例报告

Akanksha Sanjay Fokmare, Rupali Shripal Parikh, Paresh R Marathe, Siddesh Tribhuvan Gupta
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引用次数: 0

摘要

接受低甲基化药物治疗的血液恶性肿瘤患者容易发生机会性感染,包括念珠菌病。我们介绍了一例被诊断为骨髓增生异常/骨髓增生性肿瘤的 73 岁女性患者的病例。在治疗过程中,外周血涂片检查发现了出芽酵母细胞,与念珠菌属一致。由于念珠菌病的症状与其他感染和化疗引起的骨髓抑制重叠,接受低甲基化药物治疗的血液恶性肿瘤患者患上念珠菌病是一项重大的临床挑战。外周涂片检查是一种快速、经济的辅助诊断工具,可用于这些患者念珠菌病的早期检测。及时发现这类人群中的念珠菌病对于适当的治疗和改善疗效至关重要。
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Peripheral blood smear diagnosis of invasive candidiasis in a patient of myelodysplastic syndrome/myeloproliferative neoplasm treated with hypomethylating agent: A case report
Patients with haematological malignancies undergoing treatment with hypomethylating agents are predisposed to opportunistic infections, including Candidiasis. We present the case of a 73-year-old female patient diagnosed with Myelodysplastic/Myeloproliferative neoplasms who was receiving a hypomethylating agent as part of her treatment regimen. During the course of her treatment, peripheral blood smear examination revealed the presence of budding yeast cells, consistent with Candida species. Subsequent culture confirmed the diagnosis of Candidiasis.The development of Candidiasis in patients with haematological malignancies receiving hypomethylating agents poses a significant clinical challenge due to overlapping symptoms with other infections and chemotherapy-induced myelosuppression. Peripheral smear examination serves as a rapid and cost-effective adjunctive diagnostic tool for the early detection of Candidiasis in these patients. Timely detection of Candidiasis in this population is critical for appropriate management and improved outcomes.
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