Yile Zheng, Yi Wei, Yuying Yang, Xiang Wen, Cai Yang, Yating Xiao, Zhen Du, Xiangsheng Liu
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引用次数: 0
摘要
光活化一氧化碳释放分子（CORMs）通常以过渡金属羰基复合物为基础，依赖紫外线或可见光激活，限制了其生物医学应用。为了解决这一局限性，我们提出了一种近红外（NIR）响应式纳米平台，该平台基于上转换纳米粒子（UCNPs），装载羰基锰络合物 Mn2(CO)10，可同时释放一氧化碳和锰离子（Mn2+）。有了这种 UCNPs，组织穿透性更强的近红外被用来在局部产生紫外线，使 Mn2(CO)10 光分解成 CO 和氧化锰（MnOX），然后 MnOX 被癌细胞中过度表达的谷胱甘肽还原成 Mn2+。此外，释放的 Mn2+ 可作为磁共振成像对比剂，实时监测近红外控制的 CO 和 Mn2+ 核心释放。因此，这种纳米平台可为近红外时空释放 CO 和 Mn2+ 提供一种潜在的策略，从而增强 CORMs 的可控递送和生物医学应用。
Development of Manganese Carbonyl Loaded Upconversion Nanoparticles for Near-Infrared-Triggered Carbon Monoxide and Mn2+ Delivery
Photoactivatable carbon monoxide-releasing molecules (CORMs), typically based on transition-metal carbonyl complexes, have reliance on activation by UV or visible light that restricts their biomedical applications. To address this limitation, a near-infrared (NIR)-responsive nanoplatform is presented based on upconversion nanoparticles (UCNPs) loading with manganese carbonyl complex Mn2(CO)10 that concurrently releases CO and manganese ion (Mn2+). With the UCNPs, the more tissue-penetrable NIR is used to locally generate UV light for photodecomposition of Mn2(CO)10 into CO and manganese oxide (MnOX), after which MnOX is reduced to Mn2+ by the overexpressed glutathione in cancer cells. Moreover, the released Mn2+ can serve as a magnetic resonance imaging contrast agent to monitor the NIR-controlled corelease of CO and Mn2+ in real time. Therefore, this nanoplatform can provide a potential strategy for NIR-enabled spatiotemporally release of CO and Mn2+, enhancing the controlled delivery and biomedical application of CORMs.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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