{"title":"维生素 C 通过调节肠道微生物群平衡缓解类风湿性关节炎。","authors":"Yanjie Zhang, Sibin Zhen, Hao Xu, Songfang Sun, Ziwei Wang, Mian Li, Liang Zou, Yangyang Zhang, Yan Zhao, Yazhou Cui, Jinxiang Han","doi":"10.5582/bst.2024.01037","DOIUrl":null,"url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and symmetric in-flammation. Our previous research revealed an imbalance in the gut flora of RA patients and showed that certain gut microbiota can accelerate RA progression by enhancing vitamin C degradation. However, it is unclear whether vitamin C supplementation could improve the gut microbiota to prevent the development of arthritis by interfering with the gut-joint axis. In this work, we aimed to evaluate the effects of vitamin C in regulating the gut microbiota and to elucidate its potential role in the onset and progression of RA in a mouse model, thus providing a basis for the development of new intervention strategies and treatments for RA. In this study, collagen-induced arthritis (CIA) mouse models, biochemical, histological and 16S rRNA microbiological methods were used to investigate the role and possible mechanism of vitamin C in rheumatoid arthritis. The results showed that treatment of CIA mice with vitamin C effectively rescued the gut mi-crobiota imbalance and suppressed the inflammatory response associated with RA, and effectively alleviated arthritis symptoms in mice in which levels of the pro-inflammatory cytokines IL-6 and TNF-α were specifi-cally reduced. In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.\",\"authors\":\"Yanjie Zhang, Sibin Zhen, Hao Xu, Songfang Sun, Ziwei Wang, Mian Li, Liang Zou, Yangyang Zhang, Yan Zhao, Yazhou Cui, Jinxiang Han\",\"doi\":\"10.5582/bst.2024.01037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and symmetric in-flammation. Our previous research revealed an imbalance in the gut flora of RA patients and showed that certain gut microbiota can accelerate RA progression by enhancing vitamin C degradation. However, it is unclear whether vitamin C supplementation could improve the gut microbiota to prevent the development of arthritis by interfering with the gut-joint axis. In this work, we aimed to evaluate the effects of vitamin C in regulating the gut microbiota and to elucidate its potential role in the onset and progression of RA in a mouse model, thus providing a basis for the development of new intervention strategies and treatments for RA. In this study, collagen-induced arthritis (CIA) mouse models, biochemical, histological and 16S rRNA microbiological methods were used to investigate the role and possible mechanism of vitamin C in rheumatoid arthritis. The results showed that treatment of CIA mice with vitamin C effectively rescued the gut mi-crobiota imbalance and suppressed the inflammatory response associated with RA, and effectively alleviated arthritis symptoms in mice in which levels of the pro-inflammatory cytokines IL-6 and TNF-α were specifi-cally reduced. In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.\",\"PeriodicalId\":8957,\"journal\":{\"name\":\"Bioscience trends\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioscience trends\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.5582/bst.2024.01037\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience trends","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.5582/bst.2024.01037","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
类风湿性关节炎(RA)是一种全身性自身免疫疾病,其特点是慢性和对称性炎症。我们之前的研究发现,类风湿性关节炎患者的肠道菌群失衡,并表明某些肠道微生物群会通过促进维生素 C 降解来加速类风湿性关节炎的恶化。然而,目前还不清楚补充维生素 C 是否能改善肠道微生物群,从而通过干扰肠道-关节轴来预防关节炎的发生。在这项工作中,我们旨在评估维生素 C 在调节肠道微生物群方面的作用,并在小鼠模型中阐明其在 RA 发病和进展中的潜在作用,从而为开发新的 RA 干预策略和治疗方法提供依据。本研究采用胶原诱导的关节炎(CIA)小鼠模型、生化、组织学和 16S rRNA 微生物学方法研究维生素 C 在类风湿关节炎中的作用和可能机制。结果表明,用维生素 C 治疗 CIA 小鼠能有效挽救肠道 mi-crobiota(微生物群)失衡,抑制与 RA 相关的炎症反应,并有效缓解小鼠的关节炎症状,其中促炎细胞因子 IL-6 和 TNF-α 的水平明显降低。总之,我们的研究结果表明,维生素 C 是治疗风湿性关节炎的一种潜在疗法。
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and symmetric in-flammation. Our previous research revealed an imbalance in the gut flora of RA patients and showed that certain gut microbiota can accelerate RA progression by enhancing vitamin C degradation. However, it is unclear whether vitamin C supplementation could improve the gut microbiota to prevent the development of arthritis by interfering with the gut-joint axis. In this work, we aimed to evaluate the effects of vitamin C in regulating the gut microbiota and to elucidate its potential role in the onset and progression of RA in a mouse model, thus providing a basis for the development of new intervention strategies and treatments for RA. In this study, collagen-induced arthritis (CIA) mouse models, biochemical, histological and 16S rRNA microbiological methods were used to investigate the role and possible mechanism of vitamin C in rheumatoid arthritis. The results showed that treatment of CIA mice with vitamin C effectively rescued the gut mi-crobiota imbalance and suppressed the inflammatory response associated with RA, and effectively alleviated arthritis symptoms in mice in which levels of the pro-inflammatory cytokines IL-6 and TNF-α were specifi-cally reduced. In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.
期刊介绍:
BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.