{"title":"前驱帕金森病快速进展的预测因素:一项纵向随访研究。","authors":"Peng Liu, Linxi Chen, Xinwei He, Lingqun Mao","doi":"10.1159/000538515","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\nParkinson's disease (PD) is characterized by a prodromal phase preceding the onset of classic motor symptoms. The duration and clinical manifestations of prodromal PD vary widely, indicating underlying heterogeneity within this stage. This discrepancy prompts the question of whether specific factors contribute to the divergent rates of progression in prodromal PD.\n\n\nMETHODS\nThis study included prodromal PD patients from the Parkinson's Progression Markers Initiative. They were followed up to assess the disease progression. The data collected during the follow-up period were analyzed to identify potential predictors of rapid disease progression in prodromal PD.\n\n\nRESULTS\nIn this study, 61 individuals with prodromal PD were enrolled. Among them, 43 patients presented with both RBD and hyposmia, 17 had hyposmia alone, and 1 had RBD alone at baseline. 13 (21.3%) prodromal PD participants exhibited rapid disease progression, with two of these cases advancing to non-neurological diseases. Significant differences were observed between the rapid progression group and no rapid progression group in terms of MDS-UPDRS II score and UPSIT score. Longitudinal analysis showed a significant increase in the MDS-UPDRS III score and MDS-UPDRS total score in the rapid progression group. Regression analyses identified the MDS-UPDRS II score and UPSIT score as predictors of rapid disease progression in prodromal PD.\n\n\nCONCLUSION\nOur study findings suggest that the MDS-UPDRS II score and UPSIT score may serve as clinical markers associated with rapid disease progression. Further research and development of precise biomarkers and advanced assessment methods are needed to enhance our understanding of prodromal PD and its progression patterns.","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictors of the rapid progression in prodromal Parkinson's disease: a longitudinal follow-up study.\",\"authors\":\"Peng Liu, Linxi Chen, Xinwei He, Lingqun Mao\",\"doi\":\"10.1159/000538515\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION\\nParkinson's disease (PD) is characterized by a prodromal phase preceding the onset of classic motor symptoms. The duration and clinical manifestations of prodromal PD vary widely, indicating underlying heterogeneity within this stage. 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引用次数: 0
摘要
简介帕金森病(PD)的特点是在典型运动症状出现之前有一个前驱期。帕金森病前驱期的持续时间和临床表现差异很大,表明这一阶段存在潜在的异质性。这种差异引发了一个问题:是否有特定因素导致了前驱期帕金森病进展率的差异。方法:本研究纳入了帕金森病进展标志物倡议中的前驱期帕金森病患者。对这些患者进行了随访,以评估疾病的进展情况。对随访期间收集到的数据进行分析,以确定前驱型帕金森病疾病快速进展的潜在预测因素。结果本研究共纳入 61 名前驱型帕金森病患者。其中,43名患者在基线时同时伴有RBD和嗅觉减退,17名患者仅有嗅觉减退,1名患者仅有RBD。13例(21.3%)前驱型帕金森病患者的病情发展迅速,其中两例发展为非神经系统疾病。快速进展组与无快速进展组在MDS-UPDRS II评分和UPSIT评分方面存在显著差异。纵向分析表明,快速进展组的 MDS-UPDRS III 评分和 MDS-UPDRS 总分均有显著增加。回归分析表明,MDS-UPDRS II 评分和 UPSIT 评分是预测前驱型帕金森病快速进展的指标。我们需要进一步研究和开发精确的生物标志物和先进的评估方法,以加深我们对前驱型帕金森病及其进展模式的了解。
Predictors of the rapid progression in prodromal Parkinson's disease: a longitudinal follow-up study.
INTRODUCTION
Parkinson's disease (PD) is characterized by a prodromal phase preceding the onset of classic motor symptoms. The duration and clinical manifestations of prodromal PD vary widely, indicating underlying heterogeneity within this stage. This discrepancy prompts the question of whether specific factors contribute to the divergent rates of progression in prodromal PD.
METHODS
This study included prodromal PD patients from the Parkinson's Progression Markers Initiative. They were followed up to assess the disease progression. The data collected during the follow-up period were analyzed to identify potential predictors of rapid disease progression in prodromal PD.
RESULTS
In this study, 61 individuals with prodromal PD were enrolled. Among them, 43 patients presented with both RBD and hyposmia, 17 had hyposmia alone, and 1 had RBD alone at baseline. 13 (21.3%) prodromal PD participants exhibited rapid disease progression, with two of these cases advancing to non-neurological diseases. Significant differences were observed between the rapid progression group and no rapid progression group in terms of MDS-UPDRS II score and UPSIT score. Longitudinal analysis showed a significant increase in the MDS-UPDRS III score and MDS-UPDRS total score in the rapid progression group. Regression analyses identified the MDS-UPDRS II score and UPSIT score as predictors of rapid disease progression in prodromal PD.
CONCLUSION
Our study findings suggest that the MDS-UPDRS II score and UPSIT score may serve as clinical markers associated with rapid disease progression. Further research and development of precise biomarkers and advanced assessment methods are needed to enhance our understanding of prodromal PD and its progression patterns.
期刊介绍:
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.