基于回波平面成像的扩散加权磁共振成像在 0.35 T MR-Linac 上的验证

Philipp Wallimann , Marco Piccirelli , Sylwia Nowakowska , Tess Armstrong , Michael Mayinger , Andreas Boss , Andrea Bink , Matthias Guckenberger , Stephanie Tanadini-Lang , Nicolaus Andratschke , Bertrand Pouymayou
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引用次数: 0

摘要

背景和目的 研究人员探讨了在放疗期间利用磁共振成像仪获取扩散加权成像(DWI)图像进行定量反应评估的可行性。研究人员对使用 0.35 T MR-Linac 的自旋回波平面成像序列获得的 DWI 数据进行了检查,并将其与传统 3 T 扫描仪的 DWI 数据进行了比较。材料与方法研究人员使用 DWI 校准模型和七名志愿者的大脑对表观扩散系数(ADC)测量和失真校正技术进行了研究。所有 DWI 均采用两个相位编码方向进行失真校正和非共振场估计。结果MR-Linac的模型ADC测量值与3 T扫描仪记录的测量值相差3%。在模型中观察到的最大畸变在校正前为 2.0 毫米,在 MR-Linac 上校正后为 1.1 毫米,而在 3 T 扫描仪上校正前为 6.0 毫米,校正后为 3.6 毫米。通过非共振场估计,校正前脑图像的失真在 MR-Linac 上达到 2.7 毫米,在 3 T 时达到 12 毫米。b 值的选择对体内 ADC 值有很大影响。在 MR-Linac 上进行的 DWI 显示出较低的失真度,校正后的最大失真度降至 1.1 毫米。
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Validation of echo planar imaging based diffusion-weighted magnetic resonance imaging on a 0.35 T MR-Linac

Background and Purpose

The feasibility of acquiring diffusion-weighted imaging (DWI) images on an MR-Linac for quantitative response assessment during radiotherapy was explored. DWI data obtained with a Spin Echo Echo Planar Imaging sequence adapted for a 0.35 T MR-Linac were examined and compared with DWI data from a conventional 3 T scanner.

Materials and Methods

Apparent diffusion coefficient (ADC) measurements and a distortion correction technique were investigated using DWI-calibrated phantoms and in the brains of seven volunteers. All DWI utilized two phase-encoding directions for distortion correction and off-resonance field estimation. ADC maps in the brain were analyzed for automatically segmented normal tissues.

Results

Phantom ADC measurements on the MR-Linac were within a 3 % margin of those recorded by the 3 T scanner. The maximum distortion observed in the phantom was 2.0 mm prior to correction and 1.1 mm post-correction on the MR-Linac, compared to 6.0 mm before correction and 3.6 mm after correction at 3 T. In vivo, the average ADC values for gray and white matter exhibited variations of 14 % and 4 %, respectively, for different selections of b-values on the MR-Linac. Distortions in brain images before correction, estimated through the off-resonance field, reached 2.7 mm on the MR-Linac and 12 mm at 3 T.

Conclusion

Accurate ADC measurements are achievable on a 0.35 T MR-Linac, both in phantom and in vivo. The selection of b-values significantly influences ADC values in vivo. DWI on the MR-Linac demonstrated lower distortion levels, with a maximum distortion reduced to 1.1 mm after correction.

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来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
期刊最新文献
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