INVESTIGATING RADIOLOGICAL INSIGHTS OF BREAST CANCER WITH AGE AT JINNAH POSTGRADUATE MEDICAL CENTRE, KARACHI

There is a conflicting opinion regarding the association between age and breast cancer in women. This study was conducted to investigate the histopathological findings of findings and features of diagnosed patients of breast cancer about their age and radiological findings of lesions and to determine the relation of aggressive findings in different age groups. Methods: A cross-sectional study was conducted in the Radiological Department, JPMC, Karachi, from September 2022- September 2023. To ascertain if the histological characteristics of the tumors were connected to the age of the patient, the histology reports of 100 women with breast cancer diagnoses underwent examination. Grading of their cancer based on BIRAD Classification was done on the radiological findings of ultrasound and mammography. Patients between 15 and 65 years were split into five different age groups. Patients who were naive and had never had any surgical or medicinal treatment for cancer before were included. After obtaining consent, a detailed questionnaire with the required data and physical and chemical parameters was completed. Tissue samples in studies mainly included trust biopsies, large mass removal, and tissues from mastectomies. Results: People under the age of 40 were shown to have a higher incidence of grade III infiltrating ductal carcinoma (P 0.0001). Lobular carcinomas were observed more frequently in the elderly group. With advancing age, there was a discernible decline in lymphoplasmacytic stromal response, axillary lymph node metastases, and vascular invasion, all unaffected by tumor grade. Conclusion: These findings imply that the histology of breast cancer may alter with age and that older patients may exhibit less aggressive characteristics in some circumstances.