分段沉淀法制备的壳聚糖纳米粒子分散体的生物活性

IF 1 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Applied Biochemistry and Microbiology Pub Date : 2024-04-21 DOI:10.1134/S0003683824020145

E. V. Popova, N. S. Domnina, I. I. Novikova, N. M. Kovalenko, I. L. Krasnobaeva, I. M. Zorin

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引用次数: 0

摘要

通过使用不同分子量的壳聚糖在 pH 值为 5.0 和 pH 值为 7.5 的条件下进行分馏沉淀得到的壳聚糖纳米粒子分散体的抗真菌和免疫调节活性进行了评估。在 pH 值为 5 时获得的纳米颗粒分散液对 C. sativus 和 A. solani 的抑菌活性更高，这是因为在较松散的纳米颗粒中氨基的可用性更高。这种分散体具有免疫刺激活性，能提高小麦对黑褐斑病的抗性。研究还证实，壳聚糖纳米颗粒分散体的诱导剂活性明显高于原始聚合物溶液的活性。

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Biological Activity of Chitosan Nanoparticle Dispersions Produced by Fractional Precipitation

An assessment of the antifungal and immunomodulatory activity of dispersions of chitosan nanoparticles obtained by fractional precipitation at pH 5.0 and pH 7.5 using chitosan of different molecular weights was made. The dispersion of nanoparticles obtained at pH 5 has increased fungistatic activity against C. sativus and A. solani, due to the higher availability of amino groups in looser nanoparticles. This dispersion showed immunostimulating activity, increasing the resistance of wheat to dark brown spot. It was also established that the elicitor activity of dispersions of chitosan nanoparticles is significantly higher than the activity of solutions of the original polymer.

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来源期刊

Applied Biochemistry and Microbiology 生物-生物工程与应用微生物

CiteScore

1.70

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.