Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Naruchorn Kijpaisalratana, Alana C. Jones, Catharine A. Couch, Robert J. Stanton, Pamela M. Rist, Mary Cushman, Suzanne E. Judd, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly
{"title":"REGARDS 中的欧米伽-3 脂肪酸与缺血性中风风险","authors":"Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Naruchorn Kijpaisalratana, Alana C. Jones, Catharine A. Couch, Robert J. Stanton, Pamela M. Rist, Mary Cushman, Suzanne E. Judd, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly","doi":"10.1007/s12975-024-01256-7","DOIUrl":null,"url":null,"abstract":"<p>We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (<i>n</i> = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid factors and incident stroke, linear regressions to determine associations between dietary intake and lipid factors, and the inverse odds ratio weighting (IORW) approach to test mediation. The study followed participants over a median (IQR) of 7 (3.4–11) years, and the case-cohort substudy included 1075 incident ischemic stroke and 968 non-stroke participants. One lipid factor, enriched for docosahexaenoic acid (DHA, an omega-3 fatty acid), was inversely associated with stroke risk in a base model (HR = 0.84; 95%CI 0.79–0.90; <i>P</i> = 8.33 × 10<sup>−8</sup>) and fully adjusted model (HR = 0.88; 95%CI 0.83–0.94; <i>P</i> = 2.79 × 10<sup>−4</sup>). This factor was associated with a healthy diet pattern (β = 0.21; 95%CI 0.12–0.30; <i>P</i> = 2.06 × 10<sup>−6</sup>), specifically with fish intake (β = 1.96; 95%CI 0.95–2.96; <i>P</i> = 1.36 × 10<sup>−4</sup>). DHA was a mediator between fish intake and incident ischemic stroke (30% <i>P</i> = 5.78 × 10<sup>−3</sup>). Taken together, DHA-containing plasma lipids were inversely associated with incident ischemic stroke and mediated the relationship between fish intake and stroke risk.</p>","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS\",\"authors\":\"Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Naruchorn Kijpaisalratana, Alana C. Jones, Catharine A. Couch, Robert J. Stanton, Pamela M. Rist, Mary Cushman, Suzanne E. Judd, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly\",\"doi\":\"10.1007/s12975-024-01256-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (<i>n</i> = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid factors and incident stroke, linear regressions to determine associations between dietary intake and lipid factors, and the inverse odds ratio weighting (IORW) approach to test mediation. The study followed participants over a median (IQR) of 7 (3.4–11) years, and the case-cohort substudy included 1075 incident ischemic stroke and 968 non-stroke participants. One lipid factor, enriched for docosahexaenoic acid (DHA, an omega-3 fatty acid), was inversely associated with stroke risk in a base model (HR = 0.84; 95%CI 0.79–0.90; <i>P</i> = 8.33 × 10<sup>−8</sup>) and fully adjusted model (HR = 0.88; 95%CI 0.83–0.94; <i>P</i> = 2.79 × 10<sup>−4</sup>). This factor was associated with a healthy diet pattern (β = 0.21; 95%CI 0.12–0.30; <i>P</i> = 2.06 × 10<sup>−6</sup>), specifically with fish intake (β = 1.96; 95%CI 0.95–2.96; <i>P</i> = 1.36 × 10<sup>−4</sup>). DHA was a mediator between fish intake and incident ischemic stroke (30% <i>P</i> = 5.78 × 10<sup>−3</sup>). Taken together, DHA-containing plasma lipids were inversely associated with incident ischemic stroke and mediated the relationship between fish intake and stroke risk.</p>\",\"PeriodicalId\":23237,\"journal\":{\"name\":\"Translational Stroke Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Stroke Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12975-024-01256-7\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Stroke Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12975-024-01256-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS
We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (n = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid factors and incident stroke, linear regressions to determine associations between dietary intake and lipid factors, and the inverse odds ratio weighting (IORW) approach to test mediation. The study followed participants over a median (IQR) of 7 (3.4–11) years, and the case-cohort substudy included 1075 incident ischemic stroke and 968 non-stroke participants. One lipid factor, enriched for docosahexaenoic acid (DHA, an omega-3 fatty acid), was inversely associated with stroke risk in a base model (HR = 0.84; 95%CI 0.79–0.90; P = 8.33 × 10−8) and fully adjusted model (HR = 0.88; 95%CI 0.83–0.94; P = 2.79 × 10−4). This factor was associated with a healthy diet pattern (β = 0.21; 95%CI 0.12–0.30; P = 2.06 × 10−6), specifically with fish intake (β = 1.96; 95%CI 0.95–2.96; P = 1.36 × 10−4). DHA was a mediator between fish intake and incident ischemic stroke (30% P = 5.78 × 10−3). Taken together, DHA-containing plasma lipids were inversely associated with incident ischemic stroke and mediated the relationship between fish intake and stroke risk.
期刊介绍:
Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma.
Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.