非吸烟者的内镜反流性食管炎和肺功能下降：回顾性队列研究

IF 2.4 Q2 RESPIRATORY SYSTEM Respiratory investigation Pub Date : 2024-05-01 DOI:10.1016/j.resinv.2024.04.017

Takayoshi Enokido , Yoshihisa Hiraishi , Taisuke Jo , Hirokazu Urushiyama , Akira Saito , Satoshi Noguchi , Keisuke Hosoki , Takashi Ishii , Naoya Miyashita , Kensuke Fukuda , Rei Matsuki , Chihiro Minatsuki , Takeshi Shimamoto , Hidenori Kage , Nobutake Yamamichi , Hirotaka Matsuzaki

{"title":"非吸烟者的内镜反流性食管炎和肺功能下降：回顾性队列研究","authors":"Takayoshi Enokido , Yoshihisa Hiraishi , Taisuke Jo , Hirokazu Urushiyama , Akira Saito , Satoshi Noguchi , Keisuke Hosoki , Takashi Ishii , Naoya Miyashita , Kensuke Fukuda , Rei Matsuki , Chihiro Minatsuki , Takeshi Shimamoto , Hidenori Kage , Nobutake Yamamichi , Hirotaka Matsuzaki","doi":"10.1016/j.resinv.2024.04.017","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The association between reflux esophagitis and pulmonary function remains controversial. Thus, evaluating the relationship between endoscopic reflux esophagitis and changes in pulmonary function over time in a nonsmoking population is an important clinical issue.</p></div><div><h3>Methods</h3><p>In this single-center retrospective cohort study, a medical examination database at Kameda Medical Center Makuhari was employed to identify nonsmokers who underwent upper gastrointestinal endoscopy and spirometry in 2010 and were followed up in 2015. Gastroenterologists carefully double-checked the diagnosis of reflux esophagitis. Multiple linear regression analyses were performed to compare the decline in the percentage of predicted vital capacity (%VC), forced vital capacity (%FVC), and forced expiratory volume in 1 s (%FEV<sub>1</sub>) between participants with reflux esophagitis and those without. Furthermore, using multivariable logistic regression analyses, we evaluated the factors associated with rapid decline in %VC, %FVC, and %FEV<sub>1</sub>, which is defined as a decrease of >10% in each parameter over the 5-year observation period.</p></div><div><h3>Results</h3><p>We identified 3098 eligible subjects, including 72 and 44 participants who had a Los Angeles classification grade A and B–C (severe) reflux esophagitis in 2010, respectively. The decline in %VC was significantly larger in the participants with severe reflux esophagitis than in the control subjects (standardized coefficient, −0.037; 95% confidence interval, −0.071 to −0.004). Moreover, reflux esophagitis was significantly associated with a rapid decline in %VC and %FVC but not in %FEV<sub>1</sub> (P for trend: 0.009, 0.009, and 0.276, respectively).</p></div><div><h3>Conclusions</h3><p>Severe reflux esophagitis among nonsmokers had clinical disadvantages in terms of a decline in %VC.</p></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212534524000704/pdfft?md5=5c696c4260c627cddd4845192bb96ae0&pid=1-s2.0-S2212534524000704-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Endoscopic reflux esophagitis and decline in pulmonary function in nonsmokers: A retrospective cohort study\",\"authors\":\"Takayoshi Enokido , Yoshihisa Hiraishi , Taisuke Jo , Hirokazu Urushiyama , Akira Saito , Satoshi Noguchi , Keisuke Hosoki , Takashi Ishii , Naoya Miyashita , Kensuke Fukuda , Rei Matsuki , Chihiro Minatsuki , Takeshi Shimamoto , Hidenori Kage , Nobutake Yamamichi , Hirotaka Matsuzaki\",\"doi\":\"10.1016/j.resinv.2024.04.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The association between reflux esophagitis and pulmonary function remains controversial. Thus, evaluating the relationship between endoscopic reflux esophagitis and changes in pulmonary function over time in a nonsmoking population is an important clinical issue.</p></div><div><h3>Methods</h3><p>In this single-center retrospective cohort study, a medical examination database at Kameda Medical Center Makuhari was employed to identify nonsmokers who underwent upper gastrointestinal endoscopy and spirometry in 2010 and were followed up in 2015. Gastroenterologists carefully double-checked the diagnosis of reflux esophagitis. Multiple linear regression analyses were performed to compare the decline in the percentage of predicted vital capacity (%VC), forced vital capacity (%FVC), and forced expiratory volume in 1 s (%FEV<sub>1</sub>) between participants with reflux esophagitis and those without. Furthermore, using multivariable logistic regression analyses, we evaluated the factors associated with rapid decline in %VC, %FVC, and %FEV<sub>1</sub>, which is defined as a decrease of >10% in each parameter over the 5-year observation period.</p></div><div><h3>Results</h3><p>We identified 3098 eligible subjects, including 72 and 44 participants who had a Los Angeles classification grade A and B–C (severe) reflux esophagitis in 2010, respectively. The decline in %VC was significantly larger in the participants with severe reflux esophagitis than in the control subjects (standardized coefficient, −0.037; 95% confidence interval, −0.071 to −0.004). Moreover, reflux esophagitis was significantly associated with a rapid decline in %VC and %FVC but not in %FEV<sub>1</sub> (P for trend: 0.009, 0.009, and 0.276, respectively).</p></div><div><h3>Conclusions</h3><p>Severe reflux esophagitis among nonsmokers had clinical disadvantages in terms of a decline in %VC.</p></div>\",\"PeriodicalId\":20934,\"journal\":{\"name\":\"Respiratory investigation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2212534524000704/pdfft?md5=5c696c4260c627cddd4845192bb96ae0&pid=1-s2.0-S2212534524000704-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiratory investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212534524000704\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory investigation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212534524000704","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

摘要

背景反流性食管炎与肺功能之间的关系仍存在争议。因此，在非吸烟人群中评估内镜反流性食管炎与肺功能随时间变化之间的关系是一个重要的临床问题。方法在这项单中心回顾性队列研究中，研究人员利用龟田医疗中心幕张医疗中心的体检数据库，对 2010 年接受上消化道内镜检查和肺活量测定并在 2015 年接受随访的非吸烟者进行了识别。消化内科医生对反流性食管炎的诊断进行了仔细的双重检查。研究人员进行了多元线性回归分析，以比较有反流性食管炎和没有反流性食管炎的参试者的预测肺活量百分比（%VC）、用力肺活量（%FVC）和 1 秒用力呼气容积（%FEV1）的下降情况。此外，我们还使用多变量逻辑回归分析评估了与 %VC、%FVC 和 %FEV1 快速下降相关的因素，即在 5 年的观察期内每项参数下降 >10%。与对照组相比，患有严重反流性食管炎的受试者的 VVC 百分比下降幅度明显更大（标准化系数，-0.037；95% 置信区间，-0.071 至 -0.004）。此外，反流性食管炎与 %VC 和 %FVC 的快速下降显著相关，但与 %FEV1 的快速下降无关（趋势的 P 值分别为 0.009、0.009 和 0.276）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Endoscopic reflux esophagitis and decline in pulmonary function in nonsmokers: A retrospective cohort study

Background

The association between reflux esophagitis and pulmonary function remains controversial. Thus, evaluating the relationship between endoscopic reflux esophagitis and changes in pulmonary function over time in a nonsmoking population is an important clinical issue.

Methods

In this single-center retrospective cohort study, a medical examination database at Kameda Medical Center Makuhari was employed to identify nonsmokers who underwent upper gastrointestinal endoscopy and spirometry in 2010 and were followed up in 2015. Gastroenterologists carefully double-checked the diagnosis of reflux esophagitis. Multiple linear regression analyses were performed to compare the decline in the percentage of predicted vital capacity (%VC), forced vital capacity (%FVC), and forced expiratory volume in 1 s (%FEV₁) between participants with reflux esophagitis and those without. Furthermore, using multivariable logistic regression analyses, we evaluated the factors associated with rapid decline in %VC, %FVC, and %FEV₁, which is defined as a decrease of >10% in each parameter over the 5-year observation period.

Results

We identified 3098 eligible subjects, including 72 and 44 participants who had a Los Angeles classification grade A and B–C (severe) reflux esophagitis in 2010, respectively. The decline in %VC was significantly larger in the participants with severe reflux esophagitis than in the control subjects (standardized coefficient, −0.037; 95% confidence interval, −0.071 to −0.004). Moreover, reflux esophagitis was significantly associated with a rapid decline in %VC and %FVC but not in %FEV₁ (P for trend: 0.009, 0.009, and 0.276, respectively).