Allan Carlos Soares do Espírito Santo M.Sc. , Clara Sandra de Araújo Sugizaki Ph.D. , Alcides Corrêa de Morais Junior Ph.D. , Nara Aline Costa Ph.D. , Maria Marcia Bachion Ph.D. , João Felipe Mota Ph.D.
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Primary wound types included pressure injuries (58%), diabetic foot ulcers (40%), and venous ulcers (2%). The intervention duration ranged from 2 to 16 wk, with sample sizes varying from 24 to 270 patients. Notably, four studies reported a reduction in wound area and an increased healing rate with a hypercaloric, hyperproteic formula enriched with zinc and vitamins A, C, and E. However, two studies found no significant differences compared with control groups. Two other studies investigated a combination of arginine, glutamine, and β-hydroxy-β-methylbutyrate; however, they did not yield significant results, and one study favored a hyperproteic formula instead of a hyperproteic formula with arginine. This review provides evidence supporting the potential of oral nutritional supplementation to enhance the healing process of chronic wounds. 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引用次数: 0
摘要
慢性伤口的特点是长期不愈合,严重影响患者的生活质量。口服配方可促进伤口愈合,并有助于降低护理成本。本综述旨在评估口服营养补充剂对慢性伤口愈合的影响,并深入了解配方的特点。通过对 Cinahl、Embase、PubMed 和 Web of Science 数据库的全面检索,我们发现了过去十年中的九项研究,涉及 741 名年龄在 52 岁至 81.7 岁之间的患者,这些患者分布在不同的护理环境中:医院、长期护理机构和家庭护理。主要伤口类型包括压力性损伤(58%)、糖尿病足溃疡(40%)和静脉溃疡(2%)。干预持续时间从 2 周到 16 周不等,样本量从 24 例到 270 例不等。值得注意的是,有四项研究报告称,使用富含锌和维生素 A、C 和 E 的高钙、高保护配方后,伤口面积缩小,愈合率提高。另外两项研究调查了精氨酸、谷氨酰胺和β-羟基-β-甲基丁酸的组合,但结果并不明显,其中一项研究倾向于使用高保护配方,而不是含有精氨酸的高保护配方。本综述为口服营养补充剂促进慢性伤口愈合的潜力提供了证据支持。根据我们的研究结果,理想配方的特点应该是热量和蛋白质含量高,并含有抗氧化微量营养素,包括但不限于维生素 A、E、C 和锌。
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review
Chronic wounds are characterized by prolonged non-healing, significantly affecting patients' quality of life. Oral formulas may enhance the wound healing process and contribute to cost reduction in care. This review aimed to evaluate the effects of oral nutritional supplementation on chronic wound healing and provide insights into formula characteristics. A comprehensive search across Cinahl, Embase, PubMed, and Web of Science databases yielded nine studies from the past decade involving 741 patients ages 52 to 81.7 across various care settings: hospitals, long-term care facilities, and home care. Primary wound types included pressure injuries (58%), diabetic foot ulcers (40%), and venous ulcers (2%). The intervention duration ranged from 2 to 16 wk, with sample sizes varying from 24 to 270 patients. Notably, four studies reported a reduction in wound area and an increased healing rate with a hypercaloric, hyperproteic formula enriched with zinc and vitamins A, C, and E. However, two studies found no significant differences compared with control groups. Two other studies investigated a combination of arginine, glutamine, and β-hydroxy-β-methylbutyrate; however, they did not yield significant results, and one study favored a hyperproteic formula instead of a hyperproteic formula with arginine. This review provides evidence supporting the potential of oral nutritional supplementation to enhance the healing process of chronic wounds. Based on our findings, a desirable formula should be characterized by a high calorie and protein content and the inclusion of antioxidant micronutrients, including, but not limited to, vitamins A, E, C, and zinc.
期刊介绍:
Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.