Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader
{"title":"Cox7a1通过复合体IV二聚化控制骨骼肌生理机能和心脏再生","authors":"Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader","doi":"10.1016/j.devcel.2024.04.012","DOIUrl":null,"url":null,"abstract":"<p>The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV<sub>2</sub> formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, <em>cox7a1</em><sup>−/−</sup> hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of <em>cox7a1</em><sup>−/−</sup> and <em>cox7a2l</em><sup>−/−</sup> underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.</p>","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":10.7000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization\",\"authors\":\"Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader\",\"doi\":\"10.1016/j.devcel.2024.04.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV<sub>2</sub> formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, <em>cox7a1</em><sup>−/−</sup> hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of <em>cox7a1</em><sup>−/−</sup> and <em>cox7a2l</em><sup>−/−</sup> underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.</p>\",\"PeriodicalId\":11157,\"journal\":{\"name\":\"Developmental cell\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2024-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental cell\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.devcel.2024.04.012\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.devcel.2024.04.012","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization
The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1−/− hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1−/− and cox7a2l−/− underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.
期刊介绍:
Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.