Gaetano Isola, Paolo Pesce, Alessandro Polizzi, Antonino Lo Giudice, Marco Cicciù, Frank A. Scannapieco
{"title":"微创非手术疗法对牙周炎患者 C 反应蛋白、脂蛋白相关磷脂酶 A2 和临床疗效的影响：为期一年的随机对照临床试验","authors":"Gaetano Isola, Paolo Pesce, Alessandro Polizzi, Antonino Lo Giudice, Marco Cicciù, Frank A. Scannapieco","doi":"10.1002/JPER.23-0518","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Growing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) together with lipoprotein-associated phospholipase A<sub>2</sub> (Lp-PLA<sub>2</sub>) levels, and clinical periodontal outcomes in patients with periodontitis. Moreover, it was evaluated if baseline CRP levels impacted the efficacy of non-surgical periodontal therapy protocols.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Forty-two periodontitis patients were enrolled and randomly treated by means of MINST (<i>n</i> = 21) or Q-SI (<i>n</i> = 21). The outcomes assessed were serum CRP and Lp-PLA<sub>2</sub>, and periodontal parameters (probing depth [PD], clinical attachment level [CAL], full-mouth bleeding score [FMBS]), at baseline and at follow-ups at 1, 3, and 6 months and at 1 year after treatment.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>At 1 year, MINST significantly reduced, among others, mean PD (<i>p</i> = 0.007), mean CAL (<i>p</i> = 0.007), the number of pockets >4 mm (<i>p</i> = 0.011) and ≥6 mm (<i>p</i> = 0.005), and FMBS (<i>p</i> = 0.048) compared to Q-SI. Generalized multivariate analysis evidenced that high baseline CRP (<i>p</i> = 0.039) and FMBS (<i>p</i> = 0.046) levels, together with MINST treatment (<i>p</i> = 0.007) were significant predictors of PD reduction at 1-year follow-up. Moreover, the Jonckheere–Terpstra test showed that patients with high baseline CRP levels gained more benefits from MINST treatment at 1-year follow-up than they did from Q-SI.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Patients receiving MINST showed a greater reduction in CRP levels than patients with Q-SI after 1 year of follow-up. Moreover, patients with high baseline levels of CRP and Lp-PLA<sub>2</sub> gained more benefits from the MINST approach at 1-year follow-up.</p>\n </section>\n </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"95 10","pages":"949-962"},"PeriodicalIF":4.2000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0518","citationCount":"0","resultStr":"{\"title\":\"Effects of minimally invasive non-surgical therapy on C-reactive protein, lipoprotein-associated phospholipase A2, and clinical outcomes in periodontitis patients: A 1-year randomized, controlled clinical trial\",\"authors\":\"Gaetano Isola, Paolo Pesce, Alessandro Polizzi, Antonino Lo Giudice, Marco Cicciù, Frank A. Scannapieco\",\"doi\":\"10.1002/JPER.23-0518\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Growing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) together with lipoprotein-associated phospholipase A<sub>2</sub> (Lp-PLA<sub>2</sub>) levels, and clinical periodontal outcomes in patients with periodontitis. Moreover, it was evaluated if baseline CRP levels impacted the efficacy of non-surgical periodontal therapy protocols.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Forty-two periodontitis patients were enrolled and randomly treated by means of MINST (<i>n</i> = 21) or Q-SI (<i>n</i> = 21). The outcomes assessed were serum CRP and Lp-PLA<sub>2</sub>, and periodontal parameters (probing depth [PD], clinical attachment level [CAL], full-mouth bleeding score [FMBS]), at baseline and at follow-ups at 1, 3, and 6 months and at 1 year after treatment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>At 1 year, MINST significantly reduced, among others, mean PD (<i>p</i> = 0.007), mean CAL (<i>p</i> = 0.007), the number of pockets >4 mm (<i>p</i> = 0.011) and ≥6 mm (<i>p</i> = 0.005), and FMBS (<i>p</i> = 0.048) compared to Q-SI. Generalized multivariate analysis evidenced that high baseline CRP (<i>p</i> = 0.039) and FMBS (<i>p</i> = 0.046) levels, together with MINST treatment (<i>p</i> = 0.007) were significant predictors of PD reduction at 1-year follow-up. Moreover, the Jonckheere–Terpstra test showed that patients with high baseline CRP levels gained more benefits from MINST treatment at 1-year follow-up than they did from Q-SI.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Patients receiving MINST showed a greater reduction in CRP levels than patients with Q-SI after 1 year of follow-up. Moreover, patients with high baseline levels of CRP and Lp-PLA<sub>2</sub> gained more benefits from the MINST approach at 1-year follow-up.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16716,\"journal\":{\"name\":\"Journal of periodontology\",\"volume\":\"95 10\",\"pages\":\"949-962\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0518\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of periodontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/JPER.23-0518\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/JPER.23-0518","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Effects of minimally invasive non-surgical therapy on C-reactive protein, lipoprotein-associated phospholipase A2, and clinical outcomes in periodontitis patients: A 1-year randomized, controlled clinical trial
Background
Growing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) together with lipoprotein-associated phospholipase A2 (Lp-PLA2) levels, and clinical periodontal outcomes in patients with periodontitis. Moreover, it was evaluated if baseline CRP levels impacted the efficacy of non-surgical periodontal therapy protocols.
Methods
Forty-two periodontitis patients were enrolled and randomly treated by means of MINST (n = 21) or Q-SI (n = 21). The outcomes assessed were serum CRP and Lp-PLA2, and periodontal parameters (probing depth [PD], clinical attachment level [CAL], full-mouth bleeding score [FMBS]), at baseline and at follow-ups at 1, 3, and 6 months and at 1 year after treatment.
Results
At 1 year, MINST significantly reduced, among others, mean PD (p = 0.007), mean CAL (p = 0.007), the number of pockets >4 mm (p = 0.011) and ≥6 mm (p = 0.005), and FMBS (p = 0.048) compared to Q-SI. Generalized multivariate analysis evidenced that high baseline CRP (p = 0.039) and FMBS (p = 0.046) levels, together with MINST treatment (p = 0.007) were significant predictors of PD reduction at 1-year follow-up. Moreover, the Jonckheere–Terpstra test showed that patients with high baseline CRP levels gained more benefits from MINST treatment at 1-year follow-up than they did from Q-SI.
Conclusion
Patients receiving MINST showed a greater reduction in CRP levels than patients with Q-SI after 1 year of follow-up. Moreover, patients with high baseline levels of CRP and Lp-PLA2 gained more benefits from the MINST approach at 1-year follow-up.
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