作为胰腺癌治疗靶点的 L 型氨基酸转运体 1

IF 2.5 4区医学 Q3 ONCOLOGY Cancer Control Pub Date : 2024-04-29 DOI:10.1177/10732748241251583

Ragnar Norrsell, Monika Bauden, Roland Andersson, Daniel Ansari

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引用次数: 0

摘要

代谢重构是癌细胞支持生长和增殖需求的一个关键特征。包括胰腺癌在内的许多癌症的氨基酸代谢都发生了改变。细胞对氨基酸的吸收受氨基酸转运体的调节，如 L 型氨基酸转运体 1（LAT1）。越来越多的证据表明，LAT1 在胰腺癌中过度表达，预后不良。在此，我们探讨了利用 LAT1 作为胰腺癌治疗新靶点的前景。

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L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer

Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and confers a poor prognosis. Here we discuss the prospects of utilizing LAT1 as a novel target for pancreatic cancer therapy.

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来源期刊

Cancer Control ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

148

审稿时长

>12 weeks

期刊介绍： Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.