促皮质素释放激素与肥胖：从胎儿期到成年期

IF 8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Reviews Pub Date : 2024-05-03 DOI:10.1111/obr.13763

Inês Vasconcelos, Madalena von Hafe, Rui Adão, Adelino Leite-Moreira, Carmen Brás-Silva

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引用次数: 0

摘要

摘要肥胖症是全球最常见的慢性疾病之一。它是一种复杂的疾病，反映了环境影响、多种基因等位基因变异和行为因素之间的相互作用。最新进展还表明，子宫内的生物条件在能量平衡系统的编程过程中起着重要作用，并可能对肥胖和代谢性疾病风险产生影响。促肾上腺皮质激素释放激素（CRH）系列神经肽作为能量平衡的核心要素，其在肥胖病理生理学中的作用已得到评估。本综述旨在总结从胎儿期到成年期 CRH 家族肽在肥胖症病理生理学中的相关性和作用。

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Corticotropin-releasing hormone and obesity: From fetal life to adulthood

Obesity is among the most common chronic disorders, worldwide. It is a complex disease that reflects the interactions between environmental influences, multiple genetic allelic variants, and behavioral factors. Recent developments have also shown that biological conditions in utero play an important role in the programming of energy homeostasis systems and might have an impact on obesity and metabolic disease risk. The corticotropin-releasing hormone (CRH) family of neuropeptides, as a central element of energy homeostasis, has been evaluated for its role in the pathophysiology of obesity. This review aims to summarize the relevance and effects of the CRH family of peptides in the pathophysiology of obesity spanning from fetal life to adulthood.

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来源期刊

Obesity Reviews 医学-内分泌学与代谢

CiteScore

19.30

自引率

1.10%

发文量

130

审稿时长

1 months

期刊介绍： Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.